Literature DB >> 2414024

Phase II study of combination bleomycin, vincristine and high-dose methotrexate (BOM) with leucovorin rescue in advanced squamous cell carcinoma of the anal canal.

N Wilking, N Petrelli, L Herrera, A Mittelman.   

Abstract

Fifteen patients with advanced squamous cell carcinoma of the anal canal were treated with a combination of bleomycin, vincristine, and high-dose methotrexate (BOM) with leucovorin rescue. Three out of twelve patients with measurable disease had objective responses of 1, 2, and 5 months. Five of the fifteen patients had severe or life-threatening complications as a result of this treatment regimen. The narrow therapeutic index of the BOM therapy makes it a less than ideal drug combination for the treatment of advanced squamous cell carcinoma of the anal canal.

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Year:  1985        PMID： 2414024     DOI： 10.1007/bf00263905

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN： 0344-5704            Impact factor:   3.333


  12 in total

1.  Combination CCNU and bleomycin therapy for squamous cell carcinoma.

Authors:  T D Lindell; H S Moseley; W S Fletcher
Journal:  Am Surg       Date:  1974-05       Impact factor: 0.688

2.  Mitomycin-C, bleomycin, vincristine, and cis-platinum in the treatment of advanced, recurrent squamous cell carcinoma of the cervix.

Authors:  D S Alberts; P W Martimbeau; E A Surwit; N Oishi
Journal:  Cancer Clin Trials       Date:  1981

3.  Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy.

Authors:  B Cummings; T Keane; G Thomas; A Harwood; W Rider
Journal:  Cancer       Date:  1984-11-15       Impact factor: 6.860

4.  Multi-modality therapy for epidermoid carcinoma of the anus.

Authors:  H K Newman; S H Quan
Journal:  Cancer       Date:  1976-01       Impact factor: 6.860

5.  Carcinoma of the anal canal. A clinical and pathologic study of 188 cases.

Authors:  B M Boman; C G Moertel; M J O'Connell; M Scott; L H Weiland; R W Beart; L L Gunderson; R J Spencer
Journal:  Cancer       Date:  1984-07-01       Impact factor: 6.860

6.  Epidermoid cancer of the anorectum.

Authors:  D B Frost; P C Richards; E D Montague; G G Giacco; R G Martin
Journal:  Cancer       Date:  1984-03-15       Impact factor: 6.860

7.  A randomized trial of the combination of cis-platinum, oncovin and bleomycin (COB) versus methotrexate in patients with advanced squamous cell carcinoma of the head and neck.

Authors:  A Drelichman; G Cummings; M Al-Sarraf
Journal:  Cancer       Date:  1983-08-01       Impact factor: 6.860

8.  Combination chemotherapy with vincristine, carmustine, carmustine (BCNU), and bleomycin in patients with squamous cell bronchial carcinoma resistant to cyclophosphamide, doxorubicin, methotrexate, and procarbazine (CAMP).

Authors:  A Veronesi; M D Magri; M G Trovò; U Tirelli; E Galligioni; S Tumolo; E Grigoletto
Journal:  Cancer Treat Rep       Date:  1982-10

9.  Combined preoperative radiation and chemotherapy for squamous cell carcinoma of the anal canal.

Authors:  N D Nigro; H G Seydel; B Considine; V K Vaitkevicius; L Leichman; J J Kinzie
Journal:  Cancer       Date:  1983-05-15       Impact factor: 6.860

10.  Malignant epithelial tumors of the anal canal.

Authors:  R Singh; F Nime; A Mittelman
Journal:  Cancer       Date:  1981-07-15       Impact factor: 6.860
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  9 in total

Review 1.  Treatment of primary epidermoid carcinoma of the anal canal.

Authors:  B J Cummings
Journal:  Int J Colorectal Dis       Date:  1987-06       Impact factor: 2.571

Review 2.  A Patient with HIV-Associated Metastatic Anal Squamous Cell Carcinoma Receiving Multimodality Therapy with Curative Intent: Case Report and Review of the Literature.

Authors:  Sunhee S Kim; Grace E Kim; Andrew H Ko
Journal:  J Gastrointest Cancer       Date:  2017-03

Review 3.  Systemic Therapies for Advanced Squamous Cell Anal Cancer.

Authors:  Francesco Sclafani; Sheela Rao
Journal:  Curr Oncol Rep       Date:  2018-05-04       Impact factor: 5.075

4.  Platinum-Fluoropyrimidine and Paclitaxel-Based Chemotherapy in the Treatment of Advanced Anal Cancer Patients.

Authors:  Francesco Sclafani; Federica Morano; David Cunningham; Chiara Baratelli; Eleftheria Kalaitzaki; David Watkins; Naureen Starling; Ian Chau; Sheela Rao
Journal:  Oncologist       Date:  2017-02-16

5.  Recurrent squamous cell carcinoma of the anal canal. Predictors of initial treatment failure and results of salvage therapy.

Authors:  W E Longo; A M Vernava; T P Wade; M A Coplin; K S Virgo; F E Johnson
Journal:  Ann Surg       Date:  1994-07       Impact factor: 12.969

Review 6.  Optimal treatment strategies for anal cancer.

Authors:  Shahab Ahmed; Cathy Eng
Journal:  Curr Treat Options Oncol       Date:  2014-09

7.  Metastatic squamous cell carcinoma of the anus: time for a shift in the treatment paradigm?

Authors:  Alice Dewdney; Sheela Rao
Journal:  ISRN Oncol       Date:  2012-05-06

8.  Clinical Practice Guideline: Anal Cancer—Diagnosis, Treatment and Follow-up

Authors:  Robert Siegel; Ricardo Niklas Werner; Stephan Koswig; Matthew Gaskins; Claus Rödel; Felix Aigner
Journal:  Dtsch Arztebl Int       Date:  2021-04-02       Impact factor: 8.251

9.  The role of systemic chemotherapy and multidisciplinary management in improving the overall survival of patients with metastatic squamous cell carcinoma of the anal canal.

Authors:  Cathy Eng; George J Chang; Y Nancy You; Prajnan Das; Miguel Rodriguez-Bigas; Yan Xing; Jean-Nicolas Vauthey; Jane E Rogers; Aki Ohinata; Priyanka Pathak; Salil Sethi; Jonathan K Phillips; Christopher H Crane; Robert A Wolff
Journal:  Oncotarget       Date:  2014-11-30
  9 in total

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