R J Bramhall1, K Mahady2, A H S Peach3. 1. Leeds General Infirmary, Great George Street, Leeds LS13EX, UK. Electronic address: rjbramhall@yahoo.co.uk. 2. Department of Radiology, Leeds General Infirmary, UK. 3. Leeds General Infirmary, Great George Street, Leeds LS13EX, UK.
Abstract
INTRODUCTION: Metastatic melanoma is poorly understood. Regression of primary lesions has been associated with poor prognosis, but spontaneous regression of all metastatic disease is clearly beneficial. A patient's own immune responses occasionally appear to stimulate spontaneous regression of metastatic disease in melanoma. PATIENTS AND METHODS: We present six interesting cases of complete or nearly complete spontaneous regression of metastatic melanoma, suggest possible causes and review the literature. RESULTS AND CONCLUSIONS: These cases show clear radiological, pathological or clinical evidence of spontaneous regression of metastatic melanoma. This remains a poorly understood phenomena warranting further investigation and may prove useful in the development of immune mediated solutions.
INTRODUCTION:Metastatic melanoma is poorly understood. Regression of primary lesions has been associated with poor prognosis, but spontaneous regression of all metastatic disease is clearly beneficial. A patient's own immune responses occasionally appear to stimulate spontaneous regression of metastatic disease in melanoma. PATIENTS AND METHODS: We present six interesting cases of complete or nearly complete spontaneous regression of metastatic melanoma, suggest possible causes and review the literature. RESULTS AND CONCLUSIONS: These cases show clear radiological, pathological or clinical evidence of spontaneous regression of metastatic melanoma. This remains a poorly understood phenomena warranting further investigation and may prove useful in the development of immune mediated solutions.
Authors: Julia A Newton-Bishop; John R Davies; Faheem Latheef; Juliette Randerson-Moor; May Chan; Jo Gascoyne; Saila Waseem; Susan Haynes; Charles O'Donovan; D Timothy Bishop Journal: Int J Cancer Date: 2014-12-13 Impact factor: 7.396
Authors: Thomas H P M Habets; Tammy Oth; Ans W Houben; Mirelle J A J Huijskens; Birgit L M G Senden-Gijsbers; Melanie C A Schnijderberg; Boudewijn Brans; Ludwig J Dubois; Philippe Lambin; Marijke De Saint-Hubert; Wilfred T V Germeraad; Marcel G J Tilanus; Felix M Mottaghy; Gerard M J Bos; Joris Vanderlocht Journal: PLoS One Date: 2016-07-18 Impact factor: 3.240