| Literature DB >> 241397 |
H Wajcman, G Gacon, D Labie, R D Koler, R T Jones.
Abstract
Hemoglobin Casper (beta106Leu replaced by Pro) can be separated from hemoglobin (Hb) A by isoelectric focusing on polyacrylamide gel. This abnormal hemoglobin was estimated to be 30% of teh total by both isoelectric focusing and heat lability kinetics. Its oxygen equilibrium curves indicate a high oxygen affinity, low degree of subunit interaction, and a decreased Bohr effect. Mixtures of Hb Casper and Hb A appear to bind oxygen as if no hybrid molecules exist.Entities:
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Year: 1975 PMID： 241397 DOI： 10.1021/bi00693a036
Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162