Wesley T O'Neal1, Jimmy T Efird2, Hope Landrine3, Curtis A Anderson4, Stephen W Davies5, Jason B O'Neal6, T Bruce Ferguson4, W Randolph Chitwood4, Alan P Kypson4. 1. Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina. Electronic address: woneal@wakehealth.edu. 2. East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, North Carolina; Center for Health Disparities, Brody School of Medicine, East Carolina University, Greenville, North Carolina. 3. Center for Health Disparities, Brody School of Medicine, East Carolina University, Greenville, North Carolina. 4. East Carolina Heart Institute, Department of Cardiovascular Sciences, Brody School of Medicine, East Carolina University, Greenville, North Carolina. 5. Department of General Surgery, University of Virginia School of Medicine, Charlottesville, Virginia. 6. Department of Anesthesia, Critical Care, and Pain Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Abstract
OBJECTIVE: To date, racial differences in the long-term survival of coronary artery bypass grafting (CABG) patients who receive preoperative β-blockers have not been specifically examined. The purpose of this study was to examine the effect of preoperative β-blockers on long-term survival among black CABG patients and to compare the magnitude of this effect with white patients. DESIGN: A retrospective cohort study. SETTING: A tertiary referral heart hospital. PARTICIPANTS: 13,354 patients undergoing CABG between 1992 and 2011. MEASUREMENTS AND MAIN RESULTS: Hazard ratios (HR) and 95% confidence intervals (CI) were computed using a Cox regression model. A total of 1,448 (62%) black and 6,094 (55%) white patients had a history of preoperative β-blocker use. Among black patients, those receiving β-blockers survived longer than those not receiving β-blockers (adjusted HR = 0.77, 95% CI = 0.67-0.88). The survival advantage was comparable to that observed among white patients (adjusted HR = 0.88, 95% CI = 0.82-0.93). CONCLUSION: Black CABG patients benefited from preoperative β-blockers and the magnitude of the effect was comparable to that among white patients.
OBJECTIVE: To date, racial differences in the long-term survival of coronary artery bypass grafting (CABG) patients who receive preoperative β-blockers have not been specifically examined. The purpose of this study was to examine the effect of preoperative β-blockers on long-term survival among black CABG patients and to compare the magnitude of this effect with white patients. DESIGN: A retrospective cohort study. SETTING: A tertiary referral heart hospital. PARTICIPANTS: 13,354 patients undergoing CABG between 1992 and 2011. MEASUREMENTS AND MAIN RESULTS: Hazard ratios (HR) and 95% confidence intervals (CI) were computed using a Cox regression model. A total of 1,448 (62%) black and 6,094 (55%) white patients had a history of preoperative β-blocker use. Among black patients, those receiving β-blockers survived longer than those not receiving β-blockers (adjusted HR = 0.77, 95% CI = 0.67-0.88). The survival advantage was comparable to that observed among white patients (adjusted HR = 0.88, 95% CI = 0.82-0.93). CONCLUSION: Black CABG patients benefited from preoperative β-blockers and the magnitude of the effect was comparable to that among white patients.
Authors: Jimmy T Efird; William F Griffin; Daniel F Sarpong; Stephen W Davies; Iulia Vann; Nathaniel T Koutlas; Ethan J Anderson; Patricia B Crane; Hope Landrine; Linda Kindell; Zahra J Iqbal; T Bruce Ferguson; W Randolph Chitwood; Alan P Kypson Journal: Int J Environ Res Public Health Date: 2015-07-06 Impact factor: 3.390
Authors: Jimmy T Efird; Wesley T O'Neal; William F Griffin; Ethan J Anderson; Stephen W Davies; Hope Landrine; Jason B O'Neal; Kristin Y Shiue; Linda C Kindell; T Bruce Ferguson; W Randolph Chitwood; Alan P Kypson Journal: Medicine (Baltimore) Date: 2015-02 Impact factor: 1.889
Authors: Jimmy T Efird; Wesley T O'Neal; Stephen W Davies; Jason B O'Neal; Linda C Kindell; Curtis A Anderson; W Randolph Chitwood; T Bruce Ferguson; Alan P Kypson Journal: Int J Environ Res Public Health Date: 2014-07-21 Impact factor: 3.390