Literature DB >> 24139420

Current and emerging therapies for Alzheimer's disease.

Haakon B Nygaard1.   

Abstract

Alzheimer's disease (AD) is a devastating neurodegenerative disorder, with a rapidly increasing worldwide prevalence. Although no cure for AD has yet been found, substantial progress has been made in our understanding of AD pathogenesis. This progress has led to the development of numerous promising compounds in various stages of clinical testing. In this review, the current pharmacologic treatments for AD are discussed in detail, followed by an overview of the main experimental strategies that will shape AD therapeutics over the next decade.
© 2013 Elsevier HS Journals, Inc. All rights reserved.

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Year:  2013        PMID: 24139420     DOI: 10.1016/j.clinthera.2013.09.009

Source DB:  PubMed          Journal:  Clin Ther        ISSN: 0149-2918            Impact factor:   3.393


  11 in total

Review 1.  Targeting Fyn Kinase in Alzheimer's Disease.

Authors:  Haakon B Nygaard
Journal:  Biol Psychiatry       Date:  2017-06-13       Impact factor: 13.382

2.  Neurocognitive challenges in brain tumor survivors: is there anything we can do?

Authors:  Lawrence Kleinberg
Journal:  J Clin Oncol       Date:  2015-04-20       Impact factor: 44.544

3.  Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons.

Authors:  Pascal Gervois; Tom Struys; Petra Hilkens; Annelies Bronckaers; Jessica Ratajczak; Constantinus Politis; Bert Brône; Ivo Lambrichts; Wendy Martens
Journal:  Stem Cells Dev       Date:  2014-10-20       Impact factor: 3.272

4.  Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease.

Authors:  Nan Jiang; Leonie H E Leithold; Julia Post; Tamar Ziehm; Jörg Mauler; Lothar Gremer; Markus Cremer; Elena Schartmann; N Jon Shah; Janine Kutzsche; Karl-Josef Langen; Jörg Breitkreutz; Dieter Willbold; Antje Willuweit
Journal:  PLoS One       Date:  2015-06-05       Impact factor: 3.240

5.  Inhibitory effect of corcin on aggregation of 1N/4R human tau protein in vitro.

Authors:  Ali Mohammadi Karakani; Gholamhossein Riazi; Seyed Mahmood Ghaffari; Shahin Ahmadian; Farzad Mokhtari; Mahshad Jalili Firuzi; Seyedeh Zahra Bathaie
Journal:  Iran J Basic Med Sci       Date:  2015-05       Impact factor: 2.699

6.  A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Authors:  Haakon B Nygaard; Allison F Wagner; Garrett S Bowen; Susan P Good; Martha G MacAvoy; Kurt A Strittmatter; Adam C Kaufman; Brian J Rosenberg; Tomoko Sekine-Konno; Pradeep Varma; Kewei Chen; Anthony J Koleske; Eric M Reiman; Stephen M Strittmatter; Christopher H van Dyck
Journal:  Alzheimers Res Ther       Date:  2015-04-14       Impact factor: 6.982

Review 7.  The Roles of Exercise and Yoga in Ameliorating Depression as a Risk Factor for Cognitive Decline.

Authors:  Danielle C Mathersul; Simon Rosenbaum
Journal:  Evid Based Complement Alternat Med       Date:  2016-12-01       Impact factor: 2.629

Review 8.  Pathophysiologic relationship between Alzheimer's disease, cerebrovascular disease, and cardiovascular risk: A review and synthesis.

Authors:  Cláudia Y Santos; Peter J Snyder; Wen-Chih Wu; Mia Zhang; Ana Echeverria; Jessica Alber
Journal:  Alzheimers Dement (Amst)       Date:  2017-02-09

9.  η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

Authors:  Michael Willem; Sabina Tahirovic; Marc Aurel Busche; Saak V Ovsepian; Magda Chafai; Scherazad Kootar; Daniel Hornburg; Lewis D B Evans; Steven Moore; Anna Daria; Heike Hampel; Veronika Müller; Camilla Giudici; Brigitte Nuscher; Andrea Wenninger-Weinzierl; Elisabeth Kremmer; Michael T Heneka; Dietmar R Thal; Vilmantas Giedraitis; Lars Lannfelt; Ulrike Müller; Frederick J Livesey; Felix Meissner; Jochen Herms; Arthur Konnerth; Hélène Marie; Christian Haass
Journal:  Nature       Date:  2015-08-31       Impact factor: 49.962

Review 10.  The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease.

Authors:  Kundlik Gadhave; Nityanand Bolshette; Ashutosh Ahire; Rohit Pardeshi; Krishan Thakur; Cristiana Trandafir; Alexandru Istrate; Sahabuddin Ahmed; Mangala Lahkar; Dafin F Muresanu; Maria Balea
Journal:  J Cell Mol Med       Date:  2016-03-29       Impact factor: 5.310

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