BACKGROUND: Chronic wounds cause significant morbidity and mortality and cost our health care system millions of dollars each year. A major impediment to wound healing is the formation of bacterial biofilms. Biofilms are communities of bacteria associated with chronic infections. OBJECTIVE: This article reviews the literature on chronic wounds and biofilms. The role of biofilms in chronic wounds is not widely known. The purpose is to increase awareness of their role and to discuss research into novel therapeutic options. METHODS: PubMed searches were performed to identify publications on chronic wounds and biofilms. RESULTS: Biofilms contribute to chronic wound nonhealing. There is an abundance of research into novel antibiofilm strategies for chronic wounds. CONCLUSION: Current research is being targeted at antibiofilm strategies needed to restore an optimal wound-healing environment. A combined treatment approach involving aggressive débridement and the addition of antibiofilm agents is needed.
BACKGROUND: Chronic wounds cause significant morbidity and mortality and cost our health care system millions of dollars each year. A major impediment to wound healing is the formation of bacterial biofilms. Biofilms are communities of bacteria associated with chronic infections. OBJECTIVE: This article reviews the literature on chronic wounds and biofilms. The role of biofilms in chronic wounds is not widely known. The purpose is to increase awareness of their role and to discuss research into novel therapeutic options. METHODS: PubMed searches were performed to identify publications on chronic wounds and biofilms. RESULTS: Biofilms contribute to chronic wound nonhealing. There is an abundance of research into novel antibiofilm strategies for chronic wounds. CONCLUSION: Current research is being targeted at antibiofilm strategies needed to restore an optimal wound-healing environment. A combined treatment approach involving aggressive débridement and the addition of antibiofilm agents is needed.
Authors: Sebastian Schlafer; Javier E Garcia; Matilde Greve; Merete K Raarup; Bente Nyvad; Irene Dige Journal: Appl Environ Microbiol Date: 2015-02 Impact factor: 4.792
Authors: Sashwati Roy; Shaurya Prakash; Shomita S Mathew-Steiner; Piya Das Ghatak; Varun Lochab; Travis H Jones; Prashanth Mohana Sundaram; Gayle M Gordillo; Vish V Subramaniam; Chandan K Sen Journal: Adv Wound Care (New Rochelle) Date: 2019-04-03 Impact factor: 4.730
Authors: Michelle S Bach; Christiaan R de Vries; Arya Khosravi; Johanna M Sweere; Medeea C Popescu; Qingquan Chen; Sally Demirdjian; Aviv Hargil; Jonas D Van Belleghem; Gernot Kaber; Maryam Hajfathalian; Elizabeth B Burgener; Dan Liu; Quynh-Lam Tran; Tejas Dharmaraj; Maria Birukova; Vivekananda Sunkari; Swathi Balaji; Nandini Ghosh; Shomita S Mathew-Steiner; Mohamed S El Masry; Sundeep G Keswani; Niaz Banaei; Laurence Nedelec; Chandan K Sen; Venita Chandra; Patrick R Secor; Gina A Suh; Paul L Bollyky Journal: Cell Rep Med Date: 2022-06-21
Authors: Katrin Mende; Kevin S Akers; Stuart D Tyner; Jason W Bennett; Mark P Simons; Dana M Blyth; Ping Li; Laveta Stewart; David R Tribble Journal: Mil Med Date: 2022-05-04 Impact factor: 1.563
Authors: Catherine L Ward; Carlos J Sanchez; Beth E Pollot; Desiree R Romano; Sharanda K Hardy; Sandra C Becerra; Christopher R Rathbone; Joseph C Wenke Journal: BMC Microbiol Date: 2015-03-28 Impact factor: 3.605
Authors: Kevin S Akers; Katrin Mende; Kristelle A Cheatle; Wendy C Zera; Xin Yu; Miriam L Beckius; Deepak Aggarwal; Ping Li; Carlos J Sanchez; Joseph C Wenke; Amy C Weintrob; David R Tribble; Clinton K Murray Journal: BMC Infect Dis Date: 2014-04-08 Impact factor: 3.090