| Literature DB >> 2413798 |
H E Gendelman, G H Pezeshkpour, N J Pressman, J S Wolinsky, R H Quarles, M J Dobersen, B D Trapp, C A Kitt, A Aksamit, R T Johnson.
Abstract
The loss of myelin-associated glycoprotein (MAG) and myelin basic protein (MBP) was compared by quantitative immunocytochemistry in demyelinating lesions of measles encephalomyelitis (ME), multiple sclerosis (MS), and progressive multifocal leukoencephalopathy (PML). Serial sections from paraffin-embedded tissue were reacted with antisera for MAG and MBP, and areas of staining loss were compared morphometrically. Lesions in ME showed MAG loss equal to that of MBP, lesions of PML showed MAG loss greater than that of MBP, and MS lesions showed a mixture of patterns. These data demonstrate distinctive patterns of MAG and MBP loss in these three diseases.Entities:
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Year: 1985 PMID： 2413798 DOI： 10.1002/ana.410180309
Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422