| Literature DB >> 24136780 |
K-C Huang1, Y-G Cherng2, L-J Chen3, C-T Hsu4, J-T Cheng5.
Abstract
A marked decrease of klotho expression was observed in the kidney of streptozotocin-induced diabetic rats (STZ rats) showing diabetic nephropathy. It has been documented that klotho is the target gene of PPARγ. However, the effect of PPARγ agonist on klotho expression in kidney of STZ rats remains obscure. Thus, we used rosiglitazone (TZD) as PPARγ agonist to investigate the effect on renal dysfunction in STZ rats. Treatment of TZD reversed the lower levels of PPARγ, klotho, and FGFR1 expressions in kidneys of STZ rats without the correction of hyperglycemia. Also, renal functions and structural defeats were improved by TZD treatment. Taken together, oral administration of TZD may improve STZ-induced diabetic nephropathy due to restoration of the expression of klotho axis through an increase in PPARγ expression without changing blood glucose in rats. © Georg Thieme Verlag KG Stuttgart · New York.Entities:
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Year: 2013 PMID： 24136780 DOI： 10.1055/s-0033-1357161
Source DB: PubMed Journal: Horm Metab Res ISSN： 0018-5043 Impact factor: 2.936