Literature DB >> 24136396

Does size matter in R&D productivity? If not, what does?

Michael Ringel1, Peter Tollman, Greg Hersch, Ulrik Schulze.   

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Year:  2013        PMID： 24136396     DOI： 10.1038/nrd4164

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  2 in total

1.  Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival.

Authors:  Paul Morgan; Piet H Van Der Graaf; John Arrowsmith; Doug E Feltner; Kira S Drummond; Craig D Wegner; Steve D A Street
Journal:  Drug Discov Today       Date:  2011-12-29       Impact factor: 7.851

2.  Smart rules: six ways to get people to solve problems without you.

Authors:  Yves Morieux
Journal:  Harv Bus Rev       Date:  2011-09
  2 in total
  22 in total

1.  Screening-based translation of public research encounters painful problems.

Authors:  Jonathan B Baell
Journal:  ACS Med Chem Lett       Date:  2015-02-09       Impact factor: 4.345

Review 2.  A decade of innovation in pharmaceutical R&D: the Chorus model.

Authors:  Paul K Owens; Eyas Raddad; Jeffrey W Miller; John R Stille; Kenneth G Olovich; Neil V Smith; Rosie S Jones; Joel C Scherer
Journal:  Nat Rev Drug Discov       Date:  2014-12-15       Impact factor: 84.694

3.  Creativity in large pharmaceutical research organizations: unleash the hungry drug hunter.

Authors:  Guy Griebel
Journal:  Br J Pharmacol       Date:  2017-04-03       Impact factor: 8.739

Review 4.  Expanding the medicinal chemistry synthetic toolbox.

Authors:  Jonas Boström; Dean G Brown; Robert J Young; György M Keserü
Journal:  Nat Rev Drug Discov       Date:  2018-08-24       Impact factor: 84.694

5.  Astrocytes and Huntington's disease.

Authors:  Baljit S Khakh; Michael V Sofroniew
Journal:  ACS Chem Neurosci       Date:  2014-05-20       Impact factor: 4.418

Review 6.  Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework.

Authors:  David Cook; Dearg Brown; Robert Alexander; Ruth March; Paul Morgan; Gemma Satterthwaite; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2014-05-16       Impact factor: 84.694

7.  R&D productivity: on the comeback trail.

Authors:  Ulrik Schulze; Mathias Baedeker; Yen Ting Chen; David Greber
Journal:  Nat Rev Drug Discov       Date:  2014-04-22       Impact factor: 84.694

Review 8.  Analysis of FDA-approved imaging agents.

Authors:  Michael S Kinch; Pamela K Woodard
Journal:  Drug Discov Today       Date:  2017-03-21       Impact factor: 7.851

Review 9.  Drug discovery effectiveness from the standpoint of therapeutic mechanisms and indications.

Authors:  Hsin-Pei Shih; Xiaodan Zhang; Alex M Aronov
Journal:  Nat Rev Drug Discov       Date:  2017-10-27       Impact factor: 84.694

10.  Impact of a five-dimensional framework on R&D productivity at AstraZeneca.

Authors:  Paul Morgan; Dean G Brown; Simon Lennard; Mark J Anderton; J Carl Barrett; Ulf Eriksson; Mark Fidock; Bengt Hamrén; Anthony Johnson; Ruth E March; James Matcham; Jerome Mettetal; David J Nicholls; Stefan Platz; Steve Rees; Michael A Snowden; Menelas N Pangalos
Journal:  Nat Rev Drug Discov       Date:  2018-01-19       Impact factor: 84.694
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