Sirpa Leivo-Korpela1, Lauri Lehtimäki2, Katriina Vuolteenaho3, Riina Nieminen3, Lea Kööbi4, Ritva Järvenpää4, Hannu Kankaanranta5, Seppo Saarelainen6, Eeva Moilanen3. 1. Department of Respiratory Medicine, Tampere University Hospital, PL 2000, 33521 Tampere, Finland; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere University Hospital, 33014 University of Tampere, Finland. Electronic address: sirpa.leivo-korpela@uta.fi. 2. Allergy Centre, Tampere University Hospital, PL 2000, 33521 Tampere, Finland; The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere University Hospital, 33014 University of Tampere, Finland. 3. The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere University Hospital, 33014 University of Tampere, Finland. 4. Department of Radiology, Tampere University Hospital, PL 2000, 33521 Tampere, Finland. 5. The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere University Hospital, 33014 University of Tampere, Finland; Department of Respiratory Medicine, Seinäjoki Central Hospital, 60220 Seinäjoki, Finland. 6. Department of Respiratory Medicine, Tampere University Hospital, PL 2000, 33521 Tampere, Finland.
Abstract
OBJECTIVES: Adipokines are protein mediators first described as products of adipose tissue regulating energy metabolism and appetite. Recently, adipokines have also been found to modulate inflammation and smooth muscle cell responses. Therefore we investigated the association of two adipokines, adiponectin and leptin, with the degree of emphysema, pulmonary function, symptoms and glucocorticoid responsiveness in patients with COPD. METHODS: Plasma adiponectin and leptin levels, spirometry, body plethysmography and symptoms were measured in 43 male COPD patients with smoking history ≥ 20 pack-years, post bronchodilator FEV1/FVC < 0.7 and pulmonary emphysema on HRCT. The measurements were repeated in a subgroup of patients after 4 weeks' treatment with inhaled fluticasone. RESULTS: In patients with COPD, plasma adiponectin levels correlated positively with airway resistance (Raw) (r = 0.362, p = 0.019) and functional residual capacity (FRC) (r = 0.355, p = 0.046). Furthermore, the baseline adiponectin concentration correlated negatively with the fluticasone induced changes in St George's Respiratory questionnaire (SGRQ) symptom score (r = -0.413, p = 0.040) and in FRC % pred (r = -0.428, p = 0.003), i.e. a higher baseline plasma adiponectin level was associated with more pronounced alleviation of symptoms and dynamic hyperinflation. Plasma leptin levels were not related to the measures of lung function, symptoms or glucocorticoid responsiveness. CONCLUSIONS: Plasma adiponectin levels were associated with peripheral airway obstruction and dynamic hyperinflation in patients with COPD. A higher adiponectin level predicted more favourable relief of symptoms and hyperinflation during glucocorticoid treatment. Adiponectin may have a role in the COPD pathogenesis; it may also be a biomarker of disease severity and treatment responses in this disease.
OBJECTIVES: Adipokines are protein mediators first described as products of adipose tissue regulating energy metabolism and appetite. Recently, adipokines have also been found to modulate inflammation and smooth muscle cell responses. Therefore we investigated the association of two adipokines, adiponectin and leptin, with the degree of emphysema, pulmonary function, symptoms and glucocorticoid responsiveness in patients with COPD. METHODS: Plasma adiponectin and leptin levels, spirometry, body plethysmography and symptoms were measured in 43 male COPDpatients with smoking history ≥ 20 pack-years, post bronchodilator FEV1/FVC < 0.7 and pulmonary emphysema on HRCT. The measurements were repeated in a subgroup of patients after 4 weeks' treatment with inhaled fluticasone. RESULTS: In patients with COPD, plasma adiponectin levels correlated positively with airway resistance (Raw) (r = 0.362, p = 0.019) and functional residual capacity (FRC) (r = 0.355, p = 0.046). Furthermore, the baseline adiponectin concentration correlated negatively with the fluticasone induced changes in St George's Respiratory questionnaire (SGRQ) symptom score (r = -0.413, p = 0.040) and in FRC % pred (r = -0.428, p = 0.003), i.e. a higher baseline plasma adiponectin level was associated with more pronounced alleviation of symptoms and dynamic hyperinflation. Plasma leptin levels were not related to the measures of lung function, symptoms or glucocorticoid responsiveness. CONCLUSIONS: Plasma adiponectin levels were associated with peripheral airway obstruction and dynamic hyperinflation in patients with COPD. A higher adiponectin level predicted more favourable relief of symptoms and hyperinflation during glucocorticoid treatment. Adiponectin may have a role in the COPD pathogenesis; it may also be a biomarker of disease severity and treatment responses in this disease.
Authors: Young Ju Suh; Merry-Lynn N McDonald; George R Washko; Brendan J Carolan; Russell P Bowler; David A Lynch; Gregory L Kinney; Jessica M Bon; Michael H Cho; James D Crapo; Elizabeth A Regan Journal: Chronic Obstr Pulm Dis Date: 2018-04-01
Authors: Hannu Kankaanranta; Pinja Ilmarinen; Terhi Kankaanranta; Leena E Tuomisto Journal: NPJ Prim Care Respir Med Date: 2015-06-25 Impact factor: 2.871