Joyce Chai1, Pak-Chung Ho. 1. Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong Special Administrative Region. Electronic address: jchai@hkucc.hku.hk.
Abstract
OBJECTIVE: To assess the feasibility of adding letrozole to the standard regimen of mifepristone and misoprostol for termination of pregnancy up to 63 days. STUDY DESIGN: We recruited 50 subjects who had requested legal termination of pregnancy up to 63 days. Medical abortion was performed with a singe dose of 200 mg mifepristone and 10 mg of letrozole daily for 3 days followed by 800 mcg vaginal misoprostol. RESULTS: The complete abortion rate was 98% (95% CI: 94-100%). The median induction-to-abortion interval of the regimen was 5.1 h (range 1.2-56 h). No serious adverse effects were reported. CONCLUSIONS: The results of this pilot study suggest that a regimen of mifepristone, letrozole and misoprostol is associated with a high complete abortion rate without major adverse events.
OBJECTIVE: To assess the feasibility of adding letrozole to the standard regimen of mifepristone and misoprostol for termination of pregnancy up to 63 days. STUDY DESIGN: We recruited 50 subjects who had requested legal termination of pregnancy up to 63 days. Medical abortion was performed with a singe dose of 200 mg mifepristone and 10 mg of letrozole daily for 3 days followed by 800 mcg vaginal misoprostol. RESULTS: The complete abortion rate was 98% (95% CI: 94-100%). The median induction-to-abortion interval of the regimen was 5.1 h (range 1.2-56 h). No serious adverse effects were reported. CONCLUSIONS: The results of this pilot study suggest that a regimen of mifepristone, letrozole and misoprostol is associated with a high complete abortion rate without major adverse events.
Authors: Libei Du; Raymond Hang Wun Li; Kristina Gemzell-Danielsson; Yan Hong Du; Li Zhang; Wei Yu Diao; Pak Chung Ho Journal: BMJ Open Date: 2022-01-31 Impact factor: 2.692