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Literature DB >> 2413362

Single-channel currents of an intercellular junction.

Abstract

We have used a double whole-cell patch-clamp system to make the first quantitative recordings of the single-channel current from an intercellular junction, presumably a gap junction. The junctional channel has various conductance states and discriminates poorly between cations and anions. It seems to change slowly from one conductance state to another.

Mesh：

Substances：
Ion Channels
Ions

Year: 1985 PMID： 2413362 DOI： 10.1038/317331a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

113 in total

1. Voltage clamp limitations of dual whole-cell gap junction current and voltage recordings. I. Conductance measurements.

Authors: R D Veenstra
Journal: Biophys J Date: 2001-05 Impact factor: 4.033

2. Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures.

Authors: M M Fróes; A H Correia; J Garcia-Abreu; D C Spray; A C Campos de Carvalho; M V Neto
Journal: Proc Natl Acad Sci U S A Date: 1999-06-22 Impact factor: 11.205

3. ATP counteracts the rundown of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation.

Authors: F Verrecchia; F Duthe; S Duval; I Duchatelle; D Sarrouilhe; J C Herve
Journal: J Physiol Date: 1999-04-15 Impact factor: 5.182

Single-channel currents of an intercellular junction.

1. Voltage clamp limitations of dual whole-cell gap junction current and voltage recordings. I. Conductance measurements.

2. Gap-junctional coupling between neurons and astrocytes in primary central nervous system cultures.

3. ATP counteracts the rundown of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation.

4. Selective inhibition of gap junction channel activity by synthetic peptides.

5. Rapid and direct effects of pH on connexins revealed by the connexin46 hemichannel preparation.

6. Functional expression of the murine connexin 36 gene coding for a neuron-specific gap junctional protein.

7. Modulation of hybrid bass retinal gap junctional channel gating by nitric oxide.

8. The influence of surface charges on the conductance of the human connexin37 gap junction channel.

9. Limitations of the dual voltage clamp method in assaying conductance and kinetics of gap junction channels.

10. Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells.