Literature DB >> 24131001

Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion.

Yu V Dmitriev1, S M Minasian, E A Demchenko, M M Galagudza.   

Abstract

The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection of necrostatin-1 (44.5 μmol/liter) caused an increase of left-ventricular systolic pressure, that is produced a positive inotropic effect, but did not reduce the infarction zone.

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Year:  2013        PMID： 24131001     DOI： 10.1007/s10517-013-2124-2

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  16 in total

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Authors:  Alexandra M Garvin; Morgan A Jackson; Donna H Korzick
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Review 2.  Necroptosis in cardiovascular disease - a new therapeutic target.

Authors:  Kartik Gupta; Noel Phan; Qiwei Wang; Bo Liu
Journal:  J Mol Cell Cardiol       Date:  2018-03-07       Impact factor: 5.000

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4.  Pleiotropic, non-cell death-associated effects of inhibitors of receptor-interacting protein kinase 1 in the heart.

Authors:  C Horvath; A Szobi; L Kindernay; T Ravingerova; A Adameova
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Review 5.  Iron overload cardiomyopathy: Using the latest evidence to inform future applications.

Authors:  Sirinart Kumfu; Siriporn C Chattipakorn; Nipon Chattipakorn
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6.  Heat shock protein 70 inhibits cardiomyocyte necroptosis through repressing autophagy in myocardial ischemia/reperfusion injury.

Authors:  Xiaojuan Liu; Chao Zhang; Chi Zhang; Jingjing Li; Wanwan Guo; Daliang Yan; Chen Yang; Jianhua Zhao; Tian Xia; Yuqing Wang; Rong Xu; Xiang Wu; Jiahai Shi
Journal:  In Vitro Cell Dev Biol Anim       Date:  2016-04-29       Impact factor: 2.416

7.  MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts.

Authors:  Dongze Qin; Xiaohong Wang; Yutian Li; Liwang Yang; Ruitao Wang; Jiangtong Peng; Kobina Essandoh; Xingjiang Mu; Tianqing Peng; Qinghua Han; Kai-Jiang Yu; Guo-Chang Fan
Journal:  J Biol Chem       Date:  2016-08-08       Impact factor: 5.157

Review 8.  Necroptosis in the Pathophysiology of Disease.

Authors:  Mitri K Khoury; Kartik Gupta; Sarah R Franco; Bo Liu
Journal:  Am J Pathol       Date:  2019-11-26       Impact factor: 4.307

Review 9.  The role of necroptosis in neurosurgical diseases.

Authors:  T Liu; Y H Bao; Y Wang; J Y Jiang
Journal:  Braz J Med Biol Res       Date:  2015-02-24       Impact factor: 2.590

Review 10.  The Role of Necroptosis in Cardiovascular Disease.

Authors:  Shi Zhe-Wei; Ge Li-Sha; Li Yue-Chun
Journal:  Front Pharmacol       Date:  2018-07-06       Impact factor: 5.810
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