Literature DB >> 24129909

Feasibility and potential role of ferumoxytol-enhanced neuroimaging in HIV-associated neurocognitive disorder.

Beau K Nakamoto1, Cecilia M Shikuma, Debra Ogata-Arakaki, Tracie Umaki, Edward A Neuwelt, Bruce T Shiramizu, Dominic C Chow, Nisha I Parikh, Kalpana J Kallianpur, Bronwyn E Hamilton.   

Abstract

We assessed ferumoxytol-enhanced brain MRI to identify monocyte/macrophage accumulation in HIV-associated neurocognitive disorder (HAND). Four HIV-infected subjects with undetectable HIV RNA levels on antiretroviral therapy, HIV DNA level in CD14+ cells ≥10 copies/10(6) cells, and cognitive impairment underwent ferumoxytol-enhanced brain MRI. On post-ferumoxytol susceptibility-weighted images, all HIV-infected subjects demonstrated a diffuse "tram track" appearance in the perivascular regions of cortical and deep white matter vessels suggesting ferumoxytol uptake in monocytes/macrophages. This finding was not present in an HIV-seronegative control. While ferumoxytol may have potential as an imaging biomarker for monocyte/macrophage accumulation in patients with HAND, future study is needed.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 24129909      PMCID： PMC3947641          DOI： 10.1007/s13365-013-0213-7

Source DB:  PubMed          Journal:  J Neurovirol        ISSN： 1355-0284            Impact factor:   2.643


  14 in total

Review 1.  Reservoirs for HIV-1: mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy.

Authors:  T Pierson; J McArthur; R F Siliciano
Journal:  Annu Rev Immunol       Date:  2000       Impact factor: 28.527

2.  Recently infiltrating MAC387(+) monocytes/macrophages a third macrophage population involved in SIV and HIV encephalitic lesion formation.

Authors:  Caroline Soulas; Cecily Conerly; Woong-Ki Kim; Tricia H Burdo; Xavier Alvarez; Andrew A Lackner; Kenneth C Williams
Journal:  Am J Pathol       Date:  2011-05       Impact factor: 4.307

3.  Influence of HAART on HIV-related CNS disease and neuroinflammation.

Authors:  I C Anthony; S N Ramage; F W Carnie; P Simmonds; J E Bell
Journal:  J Neuropathol Exp Neurol       Date:  2005-06       Impact factor: 3.685

4.  Hide and seek... Can we eradicate HIV by treatment intensification?

Authors:  Julian Schulze zur Wiesch; Jan van Lunzen
Journal:  J Infect Dis       Date:  2011-04-01       Impact factor: 5.226

5.  High-resolution steady-state cerebral blood volume maps in patients with central nervous system neoplasms using ferumoxytol, a superparamagnetic iron oxide nanoparticle.

Authors:  Csanad G Varallyay; Eric Nesbit; Rongwei Fu; Seymur Gahramanov; Brendan Moloney; Eric Earl; Leslie L Muldoon; Xin Li; William D Rooney; Edward A Neuwelt
Journal:  J Cereb Blood Flow Metab       Date:  2013-03-13       Impact factor: 6.200

6.  Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment.

Authors:  Clayton A Wiley; Brian J Lopresti; James T Becker; Fernando Boada; Oscar L Lopez; John Mellors; Carolyn C Meltzer; Stephen R Wisniewski; Chester A Mathis
Journal:  J Neurovirol       Date:  2006-08       Impact factor: 2.643

7.  Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS.

Authors:  Dima A Hammoud; Christopher J Endres; Ankit R Chander; Tomas R Guilarte; Dean F Wong; Ned C Sacktor; Justin C McArthur; Martin G Pomper
Journal:  J Neurovirol       Date:  2005-08       Impact factor: 2.643

Review 8.  The neuropathogenesis of AIDS.

Authors:  Francisco González-Scarano; Julio Martín-García
Journal:  Nat Rev Immunol       Date:  2005-01       Impact factor: 53.106

Review 9.  HIV-1 infection and neurocognitive impairment in the current era.

Authors:  María del Palacio; Susana Alvarez; M Ángeles Muñoz-Fernández
Journal:  Rev Med Virol       Date:  2011-09-23       Impact factor: 6.989

Review 10.  Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?

Authors:  Edward A Neuwelt; Bronwyn E Hamilton; Csanad G Varallyay; William R Rooney; Robert D Edelman; Paula M Jacobs; Suzanne G Watnick
Journal:  Kidney Int       Date:  2008-10-08       Impact factor: 10.612
View more
  2 in total

Review 1.  Interactions between ageing and NeuroAIDS.

Authors:  Joanna Hellmuth; Benedetta Milanini; Victor Valcour
Journal:  Curr Opin HIV AIDS       Date:  2014-11       Impact factor: 4.283

2.  MRI with ferumoxytol: A single center experience of safety across the age spectrum.

Authors:  Kim-Lien Nguyen; Takegawa Yoshida; Fei Han; Ihab Ayad; Brian L Reemtsen; Isidro B Salusky; Gary M Satou; Peng Hu; J Paul Finn
Journal:  J Magn Reson Imaging       Date:  2016-08-02       Impact factor: 5.119
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.