INTRODUCTION: In the present study, we sought to identify the bacterial organisms associated with diabetic foot infections (DFIs) and their antibiotic sensitivity profiles. METHODOLOGY: We retrospectively reviewed the records of wound cultures collected from diabetic patients with foot infections between May 2005 and July 2010. RESULTS: We identified a total of 298 culture specimens (165 [55%] wound swab, 108 [36%] tissue samples, and 25 [9%] bone samples) from 107 patients (74 [69%] males and 33 [31%] females, mean age 62 ± 13 yr) with a DFI. Among all cultures 83.5% (223/267) were monomicrobial and 16.4% (44/267) were polymicrobial. Gram-negative bacterial isolates (n = 191; 61.3%) significantly outnumbered Gram-positive isolates (n = 121; 38.7%). The most frequently isolated bacteria were Pseudomonas species (29.8%), Staphylococcus aureus (16.7%), Enterococcus species (11.5%), Escherichia coli (7.1%), and Enterobacter species (7.1%), respectively. While 13.2% of the Gram-negative isolates were inducible beta-lactamase positive, 44.2% of Staphylococcus aureus isolates were methicillin resistant. CONCLUSIONS: Our results support the recent view that Gram-negative organisms, depending on the geographical location, may predominate in DFIs.
INTRODUCTION: In the present study, we sought to identify the bacterial organisms associated with diabetic foot infections (DFIs) and their antibiotic sensitivity profiles. METHODOLOGY: We retrospectively reviewed the records of wound cultures collected from diabeticpatients with foot infections between May 2005 and July 2010. RESULTS: We identified a total of 298 culture specimens (165 [55%] wound swab, 108 [36%] tissue samples, and 25 [9%] bone samples) from 107 patients (74 [69%] males and 33 [31%] females, mean age 62 ± 13 yr) with a DFI. Among all cultures 83.5% (223/267) were monomicrobial and 16.4% (44/267) were polymicrobial. Gram-negative bacterial isolates (n = 191; 61.3%) significantly outnumbered Gram-positive isolates (n = 121; 38.7%). The most frequently isolated bacteria were Pseudomonas species (29.8%), Staphylococcus aureus (16.7%), Enterococcus species (11.5%), Escherichia coli (7.1%), and Enterobacter species (7.1%), respectively. While 13.2% of the Gram-negative isolates were inducible beta-lactamase positive, 44.2% of Staphylococcus aureus isolates were methicillin resistant. CONCLUSIONS: Our results support the recent view that Gram-negative organisms, depending on the geographical location, may predominate in DFIs.
Authors: Helen L Lydon; Niki Baccile; Breedge Callaghan; Roger Marchant; Christopher A Mitchell; Ibrahim M Banat Journal: Antimicrob Agents Chemother Date: 2017-04-24 Impact factor: 5.191
Authors: Fakhria A Al-Joufi; Khalid M Aljarallah; Soheir A Hagras; Ibrahim M Al Hosiny; Mounir M Salem-Bekhit; Abdullah M E Youssof; Faiyaz Shakeel Journal: 3 Biotech Date: 2020-06-30 Impact factor: 2.406
Authors: Vanessa Silva; Cecília Peirone; Rosa Capita; Carlos Alonso-Calleja; José A Marques-Magallanes; Isabel Pires; Luís Maltez; José Eduardo Pereira; Gilberto Igrejas; Patrícia Poeta Journal: Biology (Basel) Date: 2021-04-26