Literature DB >> 2412959

Two apparently nonrepeated epitopes on gametes of Plasmodium falciparum are targets of transmission-blocking antibodies.

R Carter, G Bushell, A Saul, P M Graves, C Kidson.   

Abstract

One-site and two-site immunoradiometric assays have been developed against an antigen on gametocytes of Plasmodium falciparum, using monoclonal antibodies (Mabs) which block transmission of the parasites to mosquitoes. Three such Mabs have been studied, each of which immunoprecipitates a complex of three gamete surface proteins of apparent Mr 260,000, 59,000, and 53,000 from Triton X-100 extracts of the parasites. The assays showed that the Mabs recognized one or the other of two distinct, nonrepeated epitopes on the target antigen(s). In the one-site assay certain combinations of two Mabs interacted at appropriate concentrations to enhance binding of the Mabs to the antigen. The same combinations of Mabs synergize to suppress infectivity of gametocytes to mosquitoes.

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Year:  1985        PMID： 2412959      PMCID： PMC262142          DOI： 10.1128/iai.50.1.102-106.1985

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  9 in total

1.  Mixing two monoclonal antibodies yields enhanced affinity for antigen.

Authors:  P H Ehrlich; W R Moyle; Z A Moustafa; R E Canfield
Journal:  J Immunol       Date:  1982-06       Impact factor: 5.422

2.  Complete in vitro maturation of Plasmodium falciparum gametocytes.

Authors:  T Ifediba; J P Vanderberg
Journal:  Nature       Date:  1981-11-26       Impact factor: 49.962

3.  Plasmodium falciparum strains from Papua New Guinea: culture characteristics and drug sensitivity.

Authors:  P Chen; G Lamont; T Elliott; C Kidson; G Brown; G Mitchell; J Stace; M Alpers
Journal:  Southeast Asian J Trop Med Public Health       Date:  1980-12       Impact factor: 0.267

4.  Effects of transmission-blocking monoclonal antibodies on different isolates of Plasmodium falciparum.

Authors:  P M Graves; R Carter; T R Burkot; J Rener; D C Kaushal; J L Williams
Journal:  Infect Immun       Date:  1985-06       Impact factor: 3.441

5.  Human malaria parasites in continuous culture.

Authors:  W Trager; J B Jensen
Journal:  Science       Date:  1976-08-20       Impact factor: 47.728

6.  Evidence for environmental modulation of gametocytogenesis in Plasmodium falciparum in continuous culture.

Authors:  R Carter; L H Miller
Journal:  Bull World Health Organ       Date:  1979       Impact factor: 9.408

7.  Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril.

Authors:  P J Fraker; J C Speck
Journal:  Biochem Biophys Res Commun       Date:  1978-02-28       Impact factor: 3.575

8.  Target antigens of transmission-blocking immunity on gametes of plasmodium falciparum.

Authors:  J Rener; P M Graves; R Carter; J L Williams; T R Burkot
Journal:  J Exp Med       Date:  1983-09-01       Impact factor: 14.307

9.  Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes.

Authors:  F Zavala; A H Cochrane; E H Nardin; R S Nussenzweig; V Nussenzweig
Journal:  J Exp Med       Date:  1983-06-01       Impact factor: 14.307
  9 in total
  6 in total

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Authors:  Frank Lennartz; Florian Brod; Rebecca Dabbs; Kazutoyo Miura; David Mekhaiel; Arianna Marini; Matthijs M Jore; Max M Søgaard; Thomas Jørgensen; Willem A de Jongh; Robert W Sauerwein; Carole A Long; Sumi Biswas; Matthew K Higgins
Journal:  Nat Commun       Date:  2018-09-20       Impact factor: 14.919

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6.  Clinically immune hosts as a refuge for drug-sensitive malaria parasites.

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  6 in total

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