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Literature DB >> 24129562

Integrin CD11c/CD18 α-chain phosphorylation is functionally important.

Liisa M Uotila¹, Maria Aatonen, Carl G Gahmberg.

Abstract

CD11c/CD18 (αXβ2, p150/95, or complement receptor 4, CR4) is a monocyte/macrophage-enriched integrin that has been reported to bind to a variety of ligands. These include cell surface proteins, extracellular matrix proteins, and soluble ligands. The regulation of ligand binding to CD11c/CD18 has remained poorly understood. Previous work has shown that both α-chain and β-chain phosphorylations of CD11a/CD18 and CD11b/CD18 are needed for activity, but no corresponding studies on CD11c/CD18 have been performed. In this study, we have identified the phosphorylation site of CD11c as Ser-1158 and show that it is pivotal for adherence and phagocytosis.

Entities: Chemical Gene

Keywords: Adhesion; Integrins; Leukocyte; Phagocytosis; Phosphorylation

Mesh：

Substances：

Year: 2013 PMID： 24129562 PMCID： PMC3829194 DOI： 10.1074/jbc.C113.497446

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

42 in total

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Review 8. Complement System Part II: Role in Immunity.

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