Byung Il Yoon1, Woong Jin Bae2, Yong Sun Choi2, Su Jin Kim2, U Syn Ha2, Sung-Hoo Hong2, Dong Wan Sohn2, Sae Woong Kim3. 1. Department of Urology, International St Mary's Hospital, The Catholic Kwandong University of Korea, Incheon, Republic of Korea. 2. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. 3. Department of Urology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea. ksw1227@catholic.ac.kr.
Abstract
OBJECTIVE: To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis (CBP) rat model. METHODS: The Sprague-Dawley rats were divided into 4 groups, including control, ciprofloxacin, anthocyanins and anthocyanins with ciprofloxacin groups (n=8 in each group). Then, drip infusion of bacterial suspension (Escherichia coli Z17 O2:K1:H-) into Sprague-Dawley rats was conducted to induce CBP. In 4 weeks, results of prostate tissue, urine culture, and histological analysis on the prostate were analyzed for each group. RESULTS: The use of ciprofloxacin, anthocyanins, and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group (P<0.05). The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group (P<0.05). CONCLUSIONS: These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects, as well as a synergistic effect with ciprofloxacin. Therefore, we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.
OBJECTIVE: To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis (CBP) rat model. METHODS: The Sprague-Dawley rats were divided into 4 groups, including control, ciprofloxacin, anthocyanins and anthocyanins with ciprofloxacin groups (n=8 in each group). Then, drip infusion of bacterial suspension (Escherichia coli Z17 O2:K1:H-) into Sprague-Dawley rats was conducted to induce CBP. In 4 weeks, results of prostate tissue, urine culture, and histological analysis on the prostate were analyzed for each group. RESULTS: The use of ciprofloxacin, anthocyanins, and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group (P<0.05). The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group (P<0.05). CONCLUSIONS: These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects, as well as a synergistic effect with ciprofloxacin. Therefore, we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success.
Authors: Liisa J Nohynek; Hanna-Leena Alakomi; Marja P Kähkönen; Marina Heinonen; Ilkka M Helander; Kirsi-Marja Oksman-Caldentey; Riitta H Puupponen-Pimiä Journal: Nutr Cancer Date: 2006 Impact factor: 2.900
Authors: Jill M Tall; Navindra P Seeram; Chengshui Zhao; Muraleedharan G Nair; Richard A Meyer; Srinivasa N Raja Journal: Behav Brain Res Date: 2004-08-12 Impact factor: 3.332