Literature DB >> 2412691

Role of mathematical modeling in protocol formulation in cancer chemotherapy.

A J Coldman, J H Goldie.   

Abstract

The origin of drug resistance is discussed and the spontaneous mutation model is presented. The general implications of this model for the use of chemotherapy are considered and are found to agree with the broad range of experience from treating human malignancy. The large amount of information required to use this model to create detailed protocols does not permit its utilization at present, but it is hoped that such information will become available in the future.

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Year:  1985        PMID： 2412691

Source DB:  PubMed          Journal:  Cancer Treat Rep        ISSN： 0361-5960


  13 in total

1.  An elementary approach to modeling drug resistance in cancer.

Authors:  Cristian Tomasetti; Doron Levy
Journal:  Math Biosci Eng       Date:  2010-10       Impact factor: 2.080

2.  On the probability of random genetic mutations for various types of tumor growth.

Authors:  Cristian Tomasetti
Journal:  Bull Math Biol       Date:  2012-02-07       Impact factor: 1.758

3.  Alternating chemotherapy in advanced gastric cancer. A phase II study.

Authors:  J Feliu; C G Girón; M González-Baron; A Berrocal; J M Barón-Saura
Journal:  Cancer Chemother Pharmacol       Date:  1991       Impact factor: 3.333

4.  Development of alkylating agent-resistant human tumor cell lines.

Authors:  B A Teicher; E Frei
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

5.  Intratumor heterogeneity in evolutionary models of tumor progression.

Authors:  Rick Durrett; Jasmine Foo; Kevin Leder; John Mayberry; Franziska Michor
Journal:  Genetics       Date:  2011-03-15       Impact factor: 4.562

6.  From passive diffusion to active cellular migration in mathematical models of tumour invasion.

Authors:  P Tracqui
Journal:  Acta Biotheor       Date:  1995-12       Impact factor: 1.774

7.  The impact of cell density and mutations in a model of multidrug resistance in solid tumors.

Authors:  James Greene; Orit Lavi; Michael M Gottesman; Doron Levy
Journal:  Bull Math Biol       Date:  2014-02-20       Impact factor: 1.758

8.  In vivo establishment and characterization of a paclitaxel-resistant human ovarian cancer cell line showing enhanced growth properties and drug-resistance only in vivo.

Authors:  Kaoru Okugawa; Hiroaki Kobayashi; Toshio Hirakawa; Takanori Sonoda; Tomonori Ogura; Hitoo Nakano
Journal:  J Cancer Res Clin Oncol       Date:  2003-12-04       Impact factor: 4.553

9.  Optimizing combination therapies with existing and future CML drugs.

Authors:  Allen A Katouli; Natalia L Komarova
Journal:  PLoS One       Date:  2010-08-23       Impact factor: 3.240

10.  The effect of one additional driver mutation on tumor progression.

Authors:  Johannes G Reiter; Ivana Bozic; Benjamin Allen; Krishnendu Chatterjee; Martin A Nowak
Journal:  Evol Appl       Date:  2012-12-10       Impact factor: 5.183
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