PURPOSE: Tumor necrosis factor-α (TNF - α) -308 G > A promoter polymorphism seems to be associated with adverse clinical outcome in hemodialysis patients (HD). Angiotensin-converting enzyme (ACE) gene may be the causative factor contributing to the deterioration of renal functions. The aim of this study was to investigate the relationship between vascular access failure and the genetic polymorphisms of ACE and TNF-α gene. METHODS: We enrolled and genotyped 47 HD patients with arteriovenous fistula (AVF) thrombosis, 51 HD patients without AVF thrombosis, and 40 healthy controls. The genotypes of these polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The genotype distribution of TNF-α -308 G > A in patients with thrombosis was significantly different from the patients without thrombosis (p = 0.008). There was no significant difference between the two groups in terms of ACE I/D polymorphism (p = 0.213). CONCLUSION: Our results propose that TNF-α -308 G > A genotype may be a potential genetic marker on HD patients with AVF thrombosis.
PURPOSE: Tumor necrosis factor-α (TNF - α) -308 G > A promoter polymorphism seems to be associated with adverse clinical outcome in hemodialysis patients (HD). Angiotensin-converting enzyme (ACE) gene may be the causative factor contributing to the deterioration of renal functions. The aim of this study was to investigate the relationship between vascular access failure and the genetic polymorphisms of ACE and TNF-α gene. METHODS: We enrolled and genotyped 47 HDpatients with arteriovenous fistula (AVF) thrombosis, 51 HDpatients without AVF thrombosis, and 40 healthy controls. The genotypes of these polymorphisms were determined by polymerase chain reaction and restriction fragment length polymorphism. RESULTS: The genotype distribution of TNF-α -308 G > A in patients with thrombosis was significantly different from the patients without thrombosis (p = 0.008). There was no significant difference between the two groups in terms of ACE I/D polymorphism (p = 0.213). CONCLUSION: Our results propose that TNF-α -308 G > A genotype may be a potential genetic marker on HDpatients with AVF thrombosis.
Authors: Donald F Brophy; Bonny L Bukaveckas; Andrea Ferreira-Gonzalez; Kellie J Archer; Erika J Martin; Todd W B Gehr Journal: Hemodial Int Date: 2009-01 Impact factor: 1.812
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Authors: Aleksandar Jankovic; Jelena Tosic; Ivana Buzadzic; Petar Djuric; Ana Bulatovic; Dragana Marković; Jovan Popovic; Nada Dimkovic Journal: Indian J Nephrol Date: 2019 Sep-Oct