Ashraf S Ibrahim1, Dimitrios P Kontoyiannis. 1. aDivision of Infectious Diseases, Harbor-University of California Los Angeles Medical Center bSt. John's Cardiovascular Research Center, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance cDavid Geffen School of Medicine at UCLA, Los Angeles, California dDepartment of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Abstract
PURPOSE OF REVIEW: Mucormycosis is an increasingly common fungal infection with unacceptably high mortality. The recent sequencing genome projects of Mucorales and the development of gene manipulation have enabled significant advances in understanding the pathogenesis of mucormycosis. Therefore, we review the pathogenesis of mucormycosis and highlight potential development of novel diagnostic and therapeutic modalities against this lethal disease. RECENT FINDINGS: Much of the work has been focused on the role of iron uptake in the virulence of Mucorales. Additionally, host receptors and fungal ligands involved in the process of tissue invasion as well as sporangiospore size and sex loci and their contribution to virulence of Mucorales are discussed. Finally, the role of innate and adaptive immunity in protection against Mucorales and new evidence about drug-induced apoptosis in these fungi are discussed. SUMMARY: Recent discoveries introduce several potentially novel diagnostic and therapeutic modalities, which are likely to improve management and outcome for mucormycosis. Future preclinical and clinical research is warranted to develop these diagnostic and therapeutic strategies.
PURPOSE OF REVIEW: Mucormycosis is an increasingly common fungal infection with unacceptably high mortality. The recent sequencing genome projects of Mucorales and the development of gene manipulation have enabled significant advances in understanding the pathogenesis of mucormycosis. Therefore, we review the pathogenesis of mucormycosis and highlight potential development of novel diagnostic and therapeutic modalities against this lethal disease. RECENT FINDINGS: Much of the work has been focused on the role of iron uptake in the virulence of Mucorales. Additionally, host receptors and fungal ligands involved in the process of tissue invasion as well as sporangiospore size and sex loci and their contribution to virulence of Mucorales are discussed. Finally, the role of innate and adaptive immunity in protection against Mucorales and new evidence about drug-induced apoptosis in these fungi are discussed. SUMMARY: Recent discoveries introduce several potentially novel diagnostic and therapeutic modalities, which are likely to improve management and outcome for mucormycosis. Future preclinical and clinical research is warranted to develop these diagnostic and therapeutic strategies.
Authors: Brad Spellberg; Ashraf S Ibrahim; Peter V Chin-Hong; Dimitrios P Kontoyiannis; Michele I Morris; John R Perfect; David Fredricks; Eric P Brass Journal: J Antimicrob Chemother Date: 2011-09-20 Impact factor: 5.790
Authors: Mingfu Liu; Brad Spellberg; Quynh T Phan; Yue Fu; Yong Fu; Amy S Lee; John E Edwards; Scott G Filler; Ashraf S Ibrahim Journal: J Clin Invest Date: 2010-05-17 Impact factor: 14.808
Authors: Georgios Chamilos; Dipyaman Ganguly; Roberto Lande; Josh Gregorio; Stephan Meller; William E Goldman; Michel Gilliet; Dimitrios P Kontoyiannis Journal: PLoS One Date: 2010-09-23 Impact factor: 3.240
Authors: A Chakrabarti; S S Chatterjee; A Das; N Panda; M R Shivaprakash; A Kaur; S C Varma; S Singhi; A Bhansali; V Sakhuja Journal: Postgrad Med J Date: 2009-11 Impact factor: 2.401
Authors: Andrii P Gryganskyi; Soo Chan Lee; Anastasia P Litvintseva; Matthew E Smith; Gregory Bonito; Teresita M Porter; Iryna M Anishchenko; Joseph Heitman; Rytas Vilgalys Journal: PLoS One Date: 2010-12-09 Impact factor: 3.240
Authors: Charles H Li; Maria Cervantes; Deborah J Springer; Teun Boekhout; Rosa M Ruiz-Vazquez; Santiago R Torres-Martinez; Joseph Heitman; Soo Chan Lee Journal: PLoS Pathog Date: 2011-06-16 Impact factor: 6.823
Authors: Tal Hover; Tal Maya; Sapir Ron; Hani Sandovsky; Yana Shadkchan; Nitzan Kijner; Yulia Mitiagin; Boris Fichtman; Amnon Harel; Robert M Q Shanks; Roberto E Bruna; Eleonora García-Véscovi; Nir Osherov Journal: Appl Environ Microbiol Date: 2016-04-18 Impact factor: 4.792
Authors: Vida Bozorgi; Mahshid Talebitaher; Neda Shalbaf; Nima Radmanesh; Fatemeh Nasri; Mohammad Mostafa Ansari-Ramandi Journal: Pan Afr Med J Date: 2016-07-13