Literature DB >> 24126590

Proteinuria: Tubular handling of albumin-degradation or salvation?

Erik I Christensen1, Henrik Birn.   

Abstract

In a recent study using transgenic mice with inducible podocyte-specific expression of tagged albumin, Tenten and colleagues report transtubular transport of albumin, possibly mediated by the neonatal Fc receptor. This study raises several questions about the physiological importance of this potential pathway and the implications for albuminuria in renal disease.

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Year:  2013        PMID： 24126590     DOI： 10.1038/nrneph.2013.212

Source DB:  PubMed          Journal:  Nat Rev Nephrol        ISSN： 1759-5061            Impact factor:   28.314


  9 in total

1.  The normal kidney filters nephrotic levels of albumin retrieved by proximal tubule cells: retrieval is disrupted in nephrotic states.

Authors:  L M Russo; R M Sandoval; M McKee; T M Osicka; A B Collins; D Brown; B A Molitoris; W D Comper
Journal:  Kidney Int       Date:  2007-01-17       Impact factor: 10.612

2.  Basolateral endocytosis of protein in isolated perfused proximal tubules.

Authors:  J T Nielsen; E I Christensen
Journal:  Kidney Int       Date:  1985-01       Impact factor: 10.612

3.  Induction of progressive glomerulonephritis by podocyte-specific overexpression of platelet-derived growth factor-D.

Authors:  Claudia R C van Roeyen; Frank Eitner; Peter Boor; Marcus J Moeller; Ute Raffetseder; Lydia Hanssen; Eva Bücher; Luigi Villa; Miriam C Banas; Kelly L Hudkins; Charles E Alpers; Tammo Ostendorf; Jürgen Floege
Journal:  Kidney Int       Date:  2011-08-24       Impact factor: 10.612

4.  Mouse model of proximal tubule endocytic dysfunction.

Authors:  Kathrin Weyer; Tina Storm; Jingdong Shan; Seppo Vainio; Renata Kozyraki; Pierre J Verroust; Erik I Christensen; Rikke Nielsen
Journal:  Nephrol Dial Transplant       Date:  2011-09-16       Impact factor: 5.992

5.  Renal FcRn reclaims albumin but facilitates elimination of IgG.

Authors:  Menaka Sarav; Ying Wang; Bradley K Hack; Anthony Chang; Mark Jensen; Lihua Bao; Richard J Quigg
Journal:  J Am Soc Nephrol       Date:  2009-08-06       Impact factor: 10.121

6.  Characterization and localization of the neonatal Fc receptor in adult human kidney.

Authors:  Jean-Philippe Haymann; Jean-Pierre Levraud; Sandrine Bouet; Vincent Kappes; Jacqueline Hagège; Genevieve Nguyen; Yichun Xu; Eric Rondeau; Jean-Daniel Sraer
Journal:  J Am Soc Nephrol       Date:  2000-04       Impact factor: 10.121

Review 7.  Renal tubule albumin transport.

Authors:  Michael Gekle
Journal:  Annu Rev Physiol       Date:  2005       Impact factor: 19.318

8.  Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.

Authors:  Manzoor A Wani; Lynn D Haynes; Jonghan Kim; C L Bronson; Chaity Chaudhury; Sudhasri Mohanty; Thomas A Waldmann; John M Robinson; Clark L Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-20       Impact factor: 11.205

9.  Albumin is recycled from the primary urine by tubular transcytosis.

Authors:  Verena Tenten; Sylvia Menzel; Uta Kunter; Eva-Maria Sicking; Claudia R C van Roeyen; Silja K Sanden; Michaela Kaldenbach; Peter Boor; Astrid Fuss; Sandra Uhlig; Regina Lanzmich; Brigith Willemsen; Henry Dijkman; Martin Grepl; Klemens Wild; Wilhelm Kriz; Bart Smeets; Jürgen Floege; Marcus J Moeller
Journal:  J Am Soc Nephrol       Date:  2013-08-22       Impact factor: 10.121
  9 in total
  8 in total

Review 1.  Drug Concentration Asymmetry in Tissues and Plasma for Small Molecule-Related Therapeutic Modalities.

Authors:  Donglu Zhang; Cornelis E C A Hop; Gabriela Patilea-Vrana; Gautham Gampa; Herana Kamal Seneviratne; Jashvant D Unadkat; Jane R Kenny; Karthik Nagapudi; Li Di; Lian Zhou; Mark Zak; Matthew R Wright; Namandjé N Bumpus; Richard Zang; Xingrong Liu; Yurong Lai; S Cyrus Khojasteh
Journal:  Drug Metab Dispos       Date:  2019-07-02       Impact factor: 3.922

2.  High glucose reduces megalin-mediated albumin endocytosis in renal proximal tubule cells through protein kinase B O-GlcNAcylation.

Authors:  Diogo de Barros Peruchetti; Rodrigo Pacheco Silva-Aguiar; Gabriela Marques Siqueira; Wagner Barbosa Dias; Celso Caruso-Neves
Journal:  J Biol Chem       Date:  2018-06-05       Impact factor: 5.157

3.  Clathrin and clathrin adaptor AP-1 control apical trafficking of megalin in the biosynthetic and recycling routes.

Authors:  Diego Gravotta; Andres Perez Bay; Caspar T H Jonker; Patrick J Zager; Ignacio Benedicto; Ryan Schreiner; Paulo S Caceres; Enrique Rodriguez-Boulan
Journal:  Mol Biol Cell       Date:  2019-05-15       Impact factor: 4.138

4.  Proteinuria is accompanied by intratubular complement activation and apical membrane deposition of C3dg and C5b-9 in kidney transplant recipients.

Authors:  Gustaf L Isaksson; Marie B Nielsen; Gitte R Hinrichs; Nicoline V Krogstrup; Rikke Zachar; Heidi Stubmark; Per Svenningsen; Kirsten Madsen; Claus Bistrup; Bente Jespersen; Henrik Birn; Yaseelan Palarasah; Boye L Jensen
Journal:  Am J Physiol Renal Physiol       Date:  2021-12-20

Review 5.  Albumin uptake and processing by the proximal tubule: physiological, pathological, and therapeutic implications.

Authors:  Bruce A Molitoris; Ruben M Sandoval; Shiv Pratap S Yadav; Mark C Wagner
Journal:  Physiol Rev       Date:  2022-04-04       Impact factor: 46.500

Review 6.  Molecular Mechanisms of Acute Organophosphate Nephrotoxicity.

Authors:  Vladislav E Sobolev; Margarita O Sokolova; Richard O Jenkins; Nikolay V Goncharov
Journal:  Int J Mol Sci       Date:  2022-08-09       Impact factor: 6.208

7.  The endocytic receptor megalin and its associated proteins in proximal tubule epithelial cells.

Authors:  Shankhajit De; Shoji Kuwahara; Akihiko Saito
Journal:  Membranes (Basel)       Date:  2014-07-11

8.  The fast-recycling receptor Megalin defines the apical recycling pathway of epithelial cells.

Authors:  Andres E Perez Bay; Ryan Schreiner; Ignacio Benedicto; Maria Paz Marzolo; Jason Banfelder; Alan M Weinstein; Enrique J Rodriguez-Boulan
Journal:  Nat Commun       Date:  2016-05-16       Impact factor: 14.919
  8 in total

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