Ayano Kutsuma1, Haruki Oshida2, Kaname Suwa3, Kei Nakajima4. 1. Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Electronic address: gvm1302@josai.ac.jp. 2. Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Electronic address: gvm1204@josai.ac.jp. 3. Saitama Health Promotion Corporation, 519 Kamiookubo, Sakura, Saitama 338-0824, Japan. Electronic address: suwa@saitama-kenkou.or.jp. 4. Division of Clinical Nutrition, Department of Medical Dietetics, Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. Electronic address: keinaka@josai.ac.jp.
Abstract
BACKGROUND: It is unknown whether low serum pepsinogen I and pepsinogen I/II ratio (PGI-PGI/II), a marker for chronic atrophic gastritis, is associated with low or high body weight. METHODS: We investigated the association between low PGI-PGI/II and both ends of the spectrum of body mass index (BMI) in 819 apparently healthy Japanese men aged 20-75 years who received a medical check-up in 2008. RESULTS: In univariate analysis, serum pepsinogen I, but not pepsinogen II or pepsinogen I/II, was significantly reduced across the increasing BMI categories. Multivariate regression analysis showed that, compared with BMI 21.0-22.9 kg/m(2), BMI of 20.9 kg/m(2) and less or 25.0 kg/m(2) and above was significantly associated with low PGI-PGI/II (pepsinogen I<50 ng/ml combined with PG I/II<3.0), even after adjustment for relevant confounders. These associations showed a J-shaped curve against BMI. CONCLUSION: Low PGI-PGI/II may be independently associated with both low body weight and obesity in Japanese men.
BACKGROUND: It is unknown whether low serum pepsinogen I and pepsinogen I/II ratio (PGI-PGI/II), a marker for chronic atrophic gastritis, is associated with low or high body weight. METHODS: We investigated the association between low PGI-PGI/II and both ends of the spectrum of body mass index (BMI) in 819 apparently healthy Japanese men aged 20-75 years who received a medical check-up in 2008. RESULTS: In univariate analysis, serum pepsinogen I, but not pepsinogen II or pepsinogen I/II, was significantly reduced across the increasing BMI categories. Multivariate regression analysis showed that, compared with BMI 21.0-22.9 kg/m(2), BMI of 20.9 kg/m(2) and less or 25.0 kg/m(2) and above was significantly associated with low PGI-PGI/II (pepsinogen I<50 ng/ml combined with PG I/II<3.0), even after adjustment for relevant confounders. These associations showed a J-shaped curve against BMI. CONCLUSION: Low PGI-PGI/II may be independently associated with both low body weight and obesity in Japanese men.
Authors: Hee Jin Kim; Nayoung Kim; Hyun Young Kim; Hye Seung Lee; Hyuk Yoon; Cheol Min Shin; Young Soo Park; Do Joong Park; Hyung Ho Kim; Kyoung-Ho Lee; Young-Hoon Kim; Hee Man Kim; Dong Ho Lee Journal: Gastric Cancer Date: 2014-09-21 Impact factor: 7.370