Julie A E Christensen1, Jacob Kempfner2, Marielle Zoetmulder3, Helle L Leonthin4, Lars Arvastson5, Søren R Christensen5, Helge B D Sorensen6, Poul Jennum7. 1. Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark; Danish Center for Sleep Medicine University of Copenhagen, Glostrup Hospital, Glostrup, Denmark. Electronic address: julie.a.e.christensen@gmail.com. 2. Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark; Danish Center for Sleep Medicine University of Copenhagen, Glostrup Hospital, Glostrup, Denmark. 3. Danish Center for Sleep Medicine University of Copenhagen, Glostrup Hospital, Glostrup, Denmark; Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark. 4. Danish Center for Sleep Medicine University of Copenhagen, Glostrup Hospital, Glostrup, Denmark. 5. H. Lundbeck A/S, Copenhagen, Denmark. 6. Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark. 7. Danish Center for Sleep Medicine University of Copenhagen, Glostrup Hospital, Glostrup, Denmark; Center for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark.
Abstract
OBJECTIVE: To determine whether sleep spindles (SS) are potentially a biomarker for Parkinson's disease (PD). METHODS: Fifteen PD patients with REM sleep behavior disorder (PD+RBD), 15 PD patients without RBD (PD-RBD), 15 idiopathic RBD (iRBD) patients and 15 age-matched controls underwent polysomnography (PSG). SS were scored in an extract of data from control subjects. An automatic SS detector using a Matching Pursuit (MP) algorithm and a Support Vector Machine (SVM) was developed and applied to the PSG recordings. The SS densities in N1, N2, N3, all NREM combined and REM sleep were obtained and evaluated across the groups. RESULTS: The SS detector achieved a sensitivity of 84.7% and a specificity of 84.5%. At a significance level of α=1%, the iRBD and PD+RBD patients had a significantly lower SS density than the control group in N2, N3 and all NREM stages combined. At a significance level of α=5%, PD-RBD had a significantly lower SS density in N2 and all NREM stages combined. CONCLUSIONS: The lower SS density suggests involvement in pre-thalamic fibers involved in SS generation. SS density is a potential early PD biomarker. SIGNIFICANCE: It is likely that an automatic SS detector could be a supportive diagnostic tool in the evaluation of iRBD and PD patients.
OBJECTIVE: To determine whether sleep spindles (SS) are potentially a biomarker for Parkinson's disease (PD). METHODS: Fifteen PDpatients with REM sleep behavior disorder (PD+RBD), 15 PDpatients without RBD (PD-RBD), 15 idiopathic RBD (iRBD) patients and 15 age-matched controls underwent polysomnography (PSG). SS were scored in an extract of data from control subjects. An automatic SS detector using a Matching Pursuit (MP) algorithm and a Support Vector Machine (SVM) was developed and applied to the PSG recordings. The SS densities in N1, N2, N3, all NREM combined and REM sleep were obtained and evaluated across the groups. RESULTS: The SS detector achieved a sensitivity of 84.7% and a specificity of 84.5%. At a significance level of α=1%, the iRBD and PD+RBD patients had a significantly lower SS density than the control group in N2, N3 and all NREM stages combined. At a significance level of α=5%, PD-RBD had a significantly lower SS density in N2 and all NREM stages combined. CONCLUSIONS: The lower SS density suggests involvement in pre-thalamic fibers involved in SS generation. SS density is a potential early PD biomarker. SIGNIFICANCE: It is likely that an automatic SS detector could be a supportive diagnostic tool in the evaluation of iRBD and PDpatients.
Authors: Sabrina L Wendt; Peter Welinder; Helge B D Sorensen; Paul E Peppard; Poul Jennum; Pietro Perona; Emmanuel Mignot; Simon C Warby Journal: Clin Neurophysiol Date: 2014-11-10 Impact factor: 3.708
Authors: Daniel J Levendowski; Luigi Ferini-Strambi; Charlene Gamaldo; Mindy Cetel; Robert Rosenberg; Philip R Westbrook Journal: J Clin Sleep Med Date: 2017-06-15 Impact factor: 4.062
Authors: Julie A E Christensen; Miki Nikolic; Simon C Warby; Henriette Koch; Marielle Zoetmulder; Rune Frandsen; Keivan K Moghadam; Helge B D Sorensen; Emmanuel Mignot; Poul J Jennum Journal: Front Hum Neurosci Date: 2015-05-01 Impact factor: 3.169