Bao-Yan Zhang1, Jing Yuan2, Zhen-Shuang Cui3, Zhong-Wu Li4, Xiang-Hong Li5, You-Yong Lu6. 1. Department of Pathology, 117 Hospital of Chinese PLA, Hangzhou, China. 2. Department of Pathology, Chinese PLA General Hospital, Beijing, China. 3. Cadre Ward of Internal Medicine, Chinese PLA General Hospital of Beijing Military Area, Beijing, China. 4. Department of Pathology, Peking University Cancer Hospital, 52 Fucheng Road, 100142 Beijing, China. 5. Department of Pathology, Peking University Cancer Hospital, 52 Fucheng Road, 100142 Beijing, China. Electronic address: lixianghong301@yahoo.com. 6. Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, 52 Fucheng Road, 100142 Beijing, China. Electronic address: youyonglu@hsc.pku.edu.cn.
Abstract
BACKGROUND: The aim of this study was to investigate the prognostic value of metastatic lymph node (LN) ratio (LNR) compared with pathologic node (pN) category. METHODS: Three hundred ninety-nine patients with gastric cancer with R0 resection were reviewed. LNR, pN, and the number of retrieved LNs were evaluated in node-positive groups with ≥15 or <15 LNs resected and a node-negative group, respectively, by univariate and multivariate analyses. Associations of pN and LNR with the number of retrieved LNs were determined using Spearman's rank correlation test. RESULTS: LNR and pN were correlated with overall survival. For the node-positive group with ≥15 LNs retrieved, pN and LNR were independent prognostic factors, with the hazard ratio higher for LNR; neither was correlated with the number of retrieved LNs. For the group with <15 LNs retrieved, LNR but not pN was an independent prognostic factor, with LNR uncorrelated with the number of LNs retrieved. For the node-negative group, the number of LNs retrieved retained an independent prognostic factor. CONCLUSIONS: LNR is an independent prognostic factor in node-positive patients with gastric cancer with R0 resection, and it is uninfluenced by the number of LNs retrieved. It may be superior to pN.
BACKGROUND: The aim of this study was to investigate the prognostic value of metastatic lymph node (LN) ratio (LNR) compared with pathologic node (pN) category. METHODS: Three hundred ninety-nine patients with gastric cancer with R0 resection were reviewed. LNR, pN, and the number of retrieved LNs were evaluated in node-positive groups with ≥15 or <15 LNs resected and a node-negative group, respectively, by univariate and multivariate analyses. Associations of pN and LNR with the number of retrieved LNs were determined using Spearman's rank correlation test. RESULTS: LNR and pN were correlated with overall survival. For the node-positive group with ≥15 LNs retrieved, pN and LNR were independent prognostic factors, with the hazard ratio higher for LNR; neither was correlated with the number of retrieved LNs. For the group with <15 LNs retrieved, LNR but not pN was an independent prognostic factor, with LNR uncorrelated with the number of LNs retrieved. For the node-negative group, the number of LNs retrieved retained an independent prognostic factor. CONCLUSIONS: LNR is an independent prognostic factor in node-positive patients with gastric cancer with R0 resection, and it is uninfluenced by the number of LNs retrieved. It may be superior to pN.
Authors: Stefano Rausei; Laura Ruspi; Federica Galli; Vincenzo Pappalardo; Giuseppe Di Rocco; Francesco Martignoni; Francesco Frattini; Francesca Rovera; Luigi Boni; Gianlorenzo Dionigi Journal: World J Gastroenterol Date: 2016-09-14 Impact factor: 5.742