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Literature DB >> 24124230

Hypoxia signaling--license to metastasize.

Abstract

Hypoxia-inducible factors (HIF) have long been linked to malignant tumor phenotypes in various cancer types, and several downstream mediators of HIF action are deregulated in metastatic carcinomas. A new study links hypoxia-induced collagen remodeling to sarcoma progression, providing evidence for unifying mechanisms of carcinoma and sarcoma metastasis. ©2013 AACR.

Entities: Chemical

Mesh：

Substances：

Year: 2013 PMID： 24124230 PMCID： PMC3889127 DOI： 10.1158/2159-8290.CD-13-0481

Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 39.397

11 in total

1. Extracellular matrix players in metastatic niches.

Authors: Thordur Oskarsson; Joan Massagué
Journal: EMBO J Date: 2011-12-16 Impact factor: 11.598

Review 2. Tumor metastasis: molecular insights and evolving paradigms.

Authors: Scott Valastyan; Robert A Weinberg
Journal: Cell Date: 2011-10-14 Impact factor: 41.582

Review 3. Advances in sarcoma genomics and new therapeutic targets.

Authors: Barry S Taylor; Jordi Barretina; Robert G Maki; Cristina R Antonescu; Samuel Singer; Marc Ladanyi
Journal: Nat Rev Cancer Date: 2011-07-14 Impact factor: 60.716

Review 4. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy.

Authors: Gregg L Semenza
Journal: Trends Pharmacol Sci Date: 2012-03-06 Impact factor: 14.819

5. Cancer statistics, 2012.

Authors: Rebecca Siegel; Deepa Naishadham; Ahmedin Jemal
Journal: CA Cancer J Clin Date: 2012-01-04 Impact factor: 508.702

6. Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis.

Authors: Daniele M Gilkes; Saumendra Bajpai; Carmen C Wong; Pallavi Chaturvedi; Maimon E Hubbi; Denis Wirtz; Gregg L Semenza
Journal: Mol Cancer Res Date: 2013-02-01 Impact factor: 5.852

Review 7. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Authors: William G Kaelin; Peter J Ratcliffe
Journal: Mol Cell Date: 2008-05-23 Impact factor: 17.970

8. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche.

Authors: Janine T Erler; Kevin L Bennewith; Thomas R Cox; Georgina Lang; Demelza Bird; Albert Koong; Quynh-Thu Le; Amato J Giaccia
Journal: Cancer Cell Date: 2009-01-06 Impact factor: 31.743

9. Collagen prolyl hydroxylases are essential for breast cancer metastasis.

Authors: Daniele M Gilkes; Pallavi Chaturvedi; Saumendra Bajpai; Carmen C Wong; Hong Wei; Stephen Pitcairn; Maimon E Hubbi; Denis Wirtz; Gregg L Semenza
Journal: Cancer Res Date: 2013-03-28 Impact factor: 12.701

10. Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.

Authors: Sakari Vanharanta; Weiping Shu; Fabienne Brenet; A Ari Hakimi; Adriana Heguy; Agnes Viale; Victor E Reuter; James J-D Hsieh; Joseph M Scandura; Joan Massagué
Journal: Nat Med Date: 2012-12-09 Impact factor: 53.440

3 in total

1. Hypoxia promotes HO-8910PM ovarian cancer cell invasion via Snail-mediated MT1-MMP upregulation.

Authors: Lijun Sun; Ping Lin; Zhuo Qin; Yusi Liu; Li-Li Deng; Changlian Lu
Journal: Exp Biol Med (Maywood) Date: 2015-02-13

2. Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer.

Authors: Meiyun Fan; Aarti Sethuraman; Martin Brown; Wenlin Sun; Lawrence M Pfeffer
Journal: Breast Cancer Res Treat Date: 2014-07-08 Impact factor: 4.872

3. Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway.

Authors: Yen-Hsiu Yeh; Ho-Fu Hsiao; Yen-Cheng Yeh; Tien-Wen Chen; Tsai-Kun Li
Journal: J Exp Clin Cancer Res Date: 2018-03-27

3 in total