OBJECTIVES: Elevations of factor IX (FIX) are thought to contribute to thrombotic risk, but this has not been well characterized. We retrospectively sought to determine whether elevated FIX levels are a risk factor for thrombosis in 81 adult subjects younger than 65 years (mean, 47 years) who were referred for evaluation of a hypercoagulable state. METHODS: Patients were classified by arterial transient ischemic attack/stroke (TIA/stroke, n = 62) or venous thromboembolism (VTE, n = 19) events. FIX activity testing was performed on all 81 subjects and a reference group of 40 healthy individuals. RESULTS: Thirteen (21%) of 62 subjects with TIA/stroke and 5 (26%) of 19 subjects with VTE had elevated FIX activity. Odds ratios for TIA/stroke and VTE in subjects with elevated FIX activity were 3.7 (95% confidence interval [CI], 0.76-17.65) and 6.8 (95% CI, 1.18-39.07), respectively. CONCLUSIONS: Our findings suggest an association between elevated FIX levels and both arterial and venous thrombotic events.
OBJECTIVES: Elevations of factor IX (FIX) are thought to contribute to thrombotic risk, but this has not been well characterized. We retrospectively sought to determine whether elevated FIX levels are a risk factor for thrombosis in 81 adult subjects younger than 65 years (mean, 47 years) who were referred for evaluation of a hypercoagulable state. METHODS:Patients were classified by arterial transient ischemic attack/stroke (TIA/stroke, n = 62) or venous thromboembolism (VTE, n = 19) events. FIX activity testing was performed on all 81 subjects and a reference group of 40 healthy individuals. RESULTS: Thirteen (21%) of 62 subjects with TIA/stroke and 5 (26%) of 19 subjects with VTE had elevated FIX activity. Odds ratios for TIA/stroke and VTE in subjects with elevated FIX activity were 3.7 (95% confidence interval [CI], 0.76-17.65) and 6.8 (95% CI, 1.18-39.07), respectively. CONCLUSIONS: Our findings suggest an association between elevated FIX levels and both arterial and venous thrombotic events.
Authors: Anne M Lynch; Brandie D Wagner; Robin R Deterding; Patricia C Giclas; Ronald S Gibbs; Edward N Janoff; V Michael Holers; Nanette F Santoro Journal: Am J Obstet Gynecol Date: 2015-11-11 Impact factor: 8.661
Authors: S B Jensen; K Hindberg; T Solomon; E N Smith; J D Lapek; D J Gonzalez; N Latysheva; K A Frazer; S K Braekkan; J-B Hansen Journal: J Thromb Haemost Date: 2018-08-06 Impact factor: 5.824
Authors: Christoph Heinz; Wolfgang Miesbach; Eva Herrmann; Michael Sonntagbauer; Florian J Raimann; Kai Zacharowski; Christian F Weber; Elisabeth H Adam Journal: Anesthesiology Date: 2021-03-01 Impact factor: 7.892