| Literature DB >> 24123885 |
Abstract
RAGE stands for Receptor of Advanced Glycation Endproducts. The two main topics discussed are (1) the nature of RAGE signaling and (2) its role in cardiovascular disease. RAGE may occur in membrane-bound form or in secretory form. RAGE signaling involves multiple ligands: (1) several AGEs (2) amyloid β pecursor protein (APP), (3) high mobility group box 1 (HMGB1), (4) S100A4, (5) S100A8/A9, and (6) S100A12, which are calcium-binding proteins, and (7) S100B, a glial-derived protein. RAGE ligands and various diseases involving RAGE signaling are summarized in tabular form.Entities:
Keywords: AGEs; Alzheimer disease; HMGB1; RAGE signaling; cancer; cardiovascular disease; diabetes mellitus; inflammation; ischemia-reperfusion injury to the heart; membrane-bound RAGE; renal disease; secretory RAGE
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Year: 2013 PMID： 24123885 DOI： 10.1002/ajmg.a.36181
Source DB: PubMed Journal: Am J Med Genet A ISSN： 1552-4825 Impact factor: 2.802