Arne Fischmann1, Jasper M Morrow, Christopher D J Sinclair, Mary M Reilly, Michael G Hanna, Tarek Yousry, John S Thornton. 1. University of Basel Hospital, Department of Radiology, Division of Diagnostic and Interventional Neuroradiology, Basel, Switzerland; University of Basel Childrens Hospital, Basel, Switzerland; MRC Centre for Neuromuscular Diseases, Department of Molecular Neuroscience, UCL Institute of Neurology, London, United Kingdom.
Abstract
PURPOSE: To compare the influence of two limb positions and slice prescription using scout-image-based and surface-anatomy-based methods on the reproducibility of quantitative MRI of lower-limb muscles. MATERIALS AND METHODS: Ten healthy subjects were scanned at 3 Tesla with a two-dimensional turbo spin-echo T1-weighted acquisition. Imaging was performed at thigh and calf level in two subject limb positions and independently repeated by a second operator. Regions-of-interest (ROI) were drawn on three muscles at thigh and calf levels on axial slices at fixed distance from the knee joint and at a level determined by surface anatomy. RESULTS: Test-retest reliability of muscle cross-sectional area and ROI area overlap were similar for both limb positioning methods. Changing limb position between scans reduced ROI overlap (P < 0.01). Scout-image-based slice prescription resulted in narrower limits of agreement and higher intraclass correlation coefficients compared with surface-anatomy-based slice prescription. CONCLUSION: Slice prescription based on fixed distance from the knee joint provided superior reproducibility of slice location than a surface anatomy-based method and should be used for longitudinal quantitative MRI studies. Exact subject positioning will depend on scanner and coil configuration, but should be consistent through a longitudinal study.
PURPOSE: To compare the influence of two limb positions and slice prescription using scout-image-based and surface-anatomy-based methods on the reproducibility of quantitative MRI of lower-limb muscles. MATERIALS AND METHODS: Ten healthy subjects were scanned at 3 Tesla with a two-dimensional turbo spin-echo T1-weighted acquisition. Imaging was performed at thigh and calf level in two subject limb positions and independently repeated by a second operator. Regions-of-interest (ROI) were drawn on three muscles at thigh and calf levels on axial slices at fixed distance from the knee joint and at a level determined by surface anatomy. RESULTS: Test-retest reliability of muscle cross-sectional area and ROI area overlap were similar for both limb positioning methods. Changing limb position between scans reduced ROI overlap (P < 0.01). Scout-image-based slice prescription resulted in narrower limits of agreement and higher intraclass correlation coefficients compared with surface-anatomy-based slice prescription. CONCLUSION: Slice prescription based on fixed distance from the knee joint provided superior reproducibility of slice location than a surface anatomy-based method and should be used for longitudinal quantitative MRI studies. Exact subject positioning will depend on scanner and coil configuration, but should be consistent through a longitudinal study.
Authors: Pierre G Carlier; Benjamin Marty; Olivier Scheidegger; Paulo Loureiro de Sousa; Pierre-Yves Baudin; Eduard Snezhko; Dmitry Vlodavets Journal: J Neuromuscul Dis Date: 2016-03-03
Authors: Jasper M Morrow; Matthew R B Evans; Tiffany Grider; Christopher D J Sinclair; Daniel Thedens; Sachit Shah; Tarek A Yousry; Michael G Hanna; Peggy Nopoulos; John S Thornton; Michael E Shy; Mary M Reilly Journal: Neurology Date: 2018-08-17 Impact factor: 9.910
Authors: Jasper M Morrow; Christopher D J Sinclair; Arne Fischmann; Mary M Reilly; Michael G Hanna; Tarek A Yousry; John S Thornton Journal: Eur Radiol Date: 2014-04-20 Impact factor: 5.315
Authors: Jasper M Morrow; Christopher D J Sinclair; Arne Fischmann; Pedro M Machado; Mary M Reilly; Tarek A Yousry; John S Thornton; Michael G Hanna Journal: Lancet Neurol Date: 2015-11-06 Impact factor: 44.182