BACKGROUND: Pathologic extracapsular extension (pECE) in metastatic lymph nodes is associated with poor prognosis for oropharyngeal carcinoma. The prognostic value of radiographic extracapsular extension (rECE) has not been studied. METHODS: A retrospective analysis was conducted of 111 patients with locally advanced oropharyngeal carcinoma treated in the Mount Sinai Radiation Oncology Department with accessible pretreatment CT reports. Univariate Kaplan-Meier and multivariate Cox regression analyses compared cohorts for locoregional control, distant control, progression-free (PFS), and overall survival (OS). RESULTS: Sixty-four patients had rECE-present and 47 had rECE-absent scans. The patients with rECE presence had significantly worse OS (3-year: 95% vs 77%; p = .006), PFS (3-year: 91% vs 71%; p = .002), and distant control (3-year: 98% vs 81%; p = .008), with no difference in locoregional control. On multivariate analysis, rECE-presence was a negative prognosticator for OS, PFS, and distant control. CONCLUSION: This study suggests that rECE is an independent prognosticator of poor distant control and survival with little impact on locoregional control for oropharyngeal carcinoma.
BACKGROUND: Pathologic extracapsular extension (pECE) in metastatic lymph nodes is associated with poor prognosis for oropharyngeal carcinoma. The prognostic value of radiographic extracapsular extension (rECE) has not been studied. METHODS: A retrospective analysis was conducted of 111 patients with locally advanced oropharyngeal carcinoma treated in the Mount Sinai Radiation Oncology Department with accessible pretreatment CT reports. Univariate Kaplan-Meier and multivariate Cox regression analyses compared cohorts for locoregional control, distant control, progression-free (PFS), and overall survival (OS). RESULTS: Sixty-four patients had rECE-present and 47 had rECE-absent scans. The patients with rECE presence had significantly worse OS (3-year: 95% vs 77%; p = .006), PFS (3-year: 91% vs 71%; p = .002), and distant control (3-year: 98% vs 81%; p = .008), with no difference in locoregional control. On multivariate analysis, rECE-presence was a negative prognosticator for OS, PFS, and distant control. CONCLUSION: This study suggests that rECE is an independent prognosticator of poor distant control and survival with little impact on locoregional control for oropharyngeal carcinoma.
Authors: Jeffrey M Vainshtein; Matthew E Spector; Mohannad Ibrahim; Carol R Bradford; Gregory T Wolf; Matthew H Stenmark; Francis P Worden; Jonathan B McHugh; Mark E Prince; Thomas Carey; Douglas B Chepeha; Avraham Eisbruch Journal: Head Neck Date: 2015-07-15 Impact factor: 3.147
Authors: A H Aiken; S Poliashenko; J J Beitler; A Y Chen; K L Baugnon; A S Corey; K R Magliocca; P A Hudgins Journal: AJNR Am J Neuroradiol Date: 2015-07-30 Impact factor: 3.825
Authors: Benjamin H Kann; Sanjay Aneja; Gokoulakrichenane V Loganadane; Jacqueline R Kelly; Stephen M Smith; Roy H Decker; James B Yu; Henry S Park; Wendell G Yarbrough; Ajay Malhotra; Barbara A Burtness; Zain A Husain Journal: Sci Rep Date: 2018-09-19 Impact factor: 4.379
Authors: Roman O Kowalchuk; Kathryn M Van Abel; Adam B Sauer; Linda X Yin; Joaquin J Garcia; William S Harmsen; Eric J Moore; Daniel L Price; Ashish V Chintakuntlawar; Katharine R Price; Scott C Lester; Michelle Neben Wittich; Samir H Patel; Robert L Foote; Daniel M Ma; Alex A Nagelschneider; David M Routman Journal: Adv Radiat Oncol Date: 2022-02-23
Authors: William Su; Jerry Liu; Brett A Miles; Eric M Genden; Krzysztof J Misiukiewicz; Marshall Posner; Vishal Gupta; Richard L Bakst Journal: PLoS One Date: 2016-12-08 Impact factor: 3.240