UNLABELLED: AIM/ BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a combined indicator of inflammation and immunology, is as yet unidentified regarding the clinical outcome of stage II and III colon cancer patients. We evaluated the effect of NLR on time-to-recurrence (TTR) and overall survival (OS) in selected patients. PATIENTS AND METHODS: A total of 504 patients with stage II and III colon cancer were included in this retrospective study. Preoperative NLR with a cut-off level of 4 was associated with TTR and OS. RESULTS: In univariate analysis, elevated NLR was significantly associated with decreased TTR (p=0.001) and remained significant in multivariate analysis (p=0.006). Patients with NLR >4 showed a median TTR of 62.2 months. In contrast, patients with NLR ≤ 4 had a median TTR of 92.6 months. CONCLUSION: This study suggests that preoperative NLR may be an independent prognostic marker for TTR in stage II and III colon cancer patients.
UNLABELLED: AIM/ BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR), a combined indicator of inflammation and immunology, is as yet unidentified regarding the clinical outcome of stage II and III colon cancerpatients. We evaluated the effect of NLR on time-to-recurrence (TTR) and overall survival (OS) in selected patients. PATIENTS AND METHODS: A total of 504 patients with stage II and III colon cancer were included in this retrospective study. Preoperative NLR with a cut-off level of 4 was associated with TTR and OS. RESULTS: In univariate analysis, elevated NLR was significantly associated with decreased TTR (p=0.001) and remained significant in multivariate analysis (p=0.006). Patients with NLR >4 showed a median TTR of 62.2 months. In contrast, patients with NLR ≤ 4 had a median TTR of 92.6 months. CONCLUSION: This study suggests that preoperative NLR may be an independent prognostic marker for TTR in stage II and III colon cancerpatients.
Entities:
Keywords:
Neutrophil-to-lymphocyte ratio; colon cancer
Authors: A Romano; N L Parrinello; M L Consoli; L Marchionni; S Forte; C Conticello; A Pompa; A Corso; G Milone; F Di Raimondo; I Borrello Journal: Ann Hematol Date: 2015-07-31 Impact factor: 3.673
Authors: Z-Y Chen; K Raghav; C H Lieu; Z-Q Jiang; C Eng; J-N Vauthey; G J Chang; W Qiao; J Morris; D Hong; P Hoff; H Tran; D G Menter; J Heymach; M Overman; S Kopetz Journal: Br J Cancer Date: 2015-03-17 Impact factor: 7.640