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Literature DB >> 24122372

In brief: Notch signalling in health and disease.

Abstract

The Notch pathway controls many aspects of development and is mutated in various human cancers. Remarkably, Notch function changes during the development of cellular hierarchies and can be either oncogenic or tumour-suppressive, depending on cellular context. Notch dysregulation is also important in cardiovascular disease and disorders of immunity. This mini-review outlines key features of the Notch signalling pathway and emerging data linking it to human diseases.

Entities: Disease Species

Keywords: Notch signalling; cancer; developmental disorders; viral infections

Mesh：

Substances：
Receptors, Notch

Year: 2014 PMID： 24122372 DOI： 10.1002/path.4291

Source DB: PubMed Journal: J Pathol ISSN： 0022-3417 Impact factor: 7.996

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Cited

19 in total

Review 1. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis.

Authors: Peter J Dempsey
Journal: Biochim Biophys Acta Mol Cell Res Date: 2017-07-22 Impact factor: 4.739

2. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.

Authors: Eric Severson; Kelly L Arnett; Hongfang Wang; Chongzhi Zang; Len Taing; Hudan Liu; Warren S Pear; X Shirley Liu; Stephen C Blacklow; Jon C Aster
Journal: Sci Signal Date: 2017-05-02 Impact factor: 8.192

Review 3. Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea.

Authors: Muhammad Waqas; Shasha Zhang; Zuhong He; Mingliang Tang; Renjie Chai
Journal: Front Med Date: 2016-09-07 Impact factor: 4.592

4. The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia.

Authors: Kaat Durinck; Annelynn Wallaert; Inge Van de Walle; Wouter Van Loocke; Pieter-Jan Volders; Suzanne Vanhauwaert; Ellen Geerdens; Yves Benoit; Nadine Van Roy; Bruce Poppe; Jean Soulier; Jan Cools; Pieter Mestdagh; Jo Vandesompele; Pieter Rondou; Pieter Van Vlierberghe; Tom Taghon; Frank Speleman
Journal: Haematologica Date: 2014-10-24 Impact factor: 9.941

5. Linking the environment, DAF-7/TGFβ signaling and LAG-2/DSL ligand expression in the germline stem cell niche.

Authors: Olga Pekar; Maria C Ow; Kailyn Y Hui; Marcus B Noyes; Sarah E Hall; E Jane Albert Hubbard
Journal: Development Date: 2017-08-15 Impact factor: 6.868

6. A herpesvirus transactivator and cellular POU proteins extensively regulate DNA binding of the host Notch signaling protein RBP-Jκ to the virus genome.

Authors: Olga Gonzalez-Lopez; Jennifer DeCotiis; Corey Goyeneche; Helena Mello; Bryan Alexis Vicente-Ortiz; Hye Jin Shin; Kyla E Driscoll; Peicheng Du; Diana Palmeri; David M Lukac
Journal: J Biol Chem Date: 2019-07-15 Impact factor: 5.157

7. Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation.

Authors: Christine Bernsmeier; Michael T Dill; Angela Provenzano; Zuzanna Makowska; Ilona Krol; Giovanna Muscogiuri; David Semela; Luigi Tornillo; Fabio Marra; Markus H Heim; François H T Duong
Journal: Lab Invest Date: 2016-07-18 Impact factor: 5.662