| Literature DB >> 24122206 |
Benping Zhang, Jianjiao Wang, Hongshuang Niu, Yang Li, Fei Yuan, Yu Tian, Fenggang Zhou, Zhen Hao, Yongri Zheng, Qingsong Li, Weizhi Wang.
Abstract
The relationship between genetic polymorphisms of glutathione S-transferase (GST) and the development of glioma has been investigated in several epidemiologic studies. However, these studies report inconsistent results. In order to get this precise result, a meta-analysis was conducted by calculating the pooled odds ratios (OR) and the 95% confidence intervals (95 % CI). Eleven case-control research studies with a total of 2,416 glioma cases and 4,850 controls were included into this meta-analysis. The combined results based on all studies showed that there was no significant association between the GSTT1 null allele and glioma risk (OR = 1.188, 95% CI = 0.929–1.520, P(heterogeneity) = 0.003, P = 0.170). In the subgroup analysis, the same results were found in our work. There was no risk of publication bias in this meta-analysis. Our results suggest that GSTT1 null genotype was not associated with the increased risk of glioma.Entities:
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Year: 2014 PMID： 24122206 DOI： 10.1007/s13277-013-1276-z
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283