Literature DB >> 24122127

Fermentation of ginseng extracts by Penicillium simplicissimum GS33 and anti-ovarian cancer activity of fermented products.

Yu Fu, Zhenhao Yin, Lunpeng Wu, Chengri Yin.   

Abstract

A total of 58 isolates of β-glucosidase-producing microorganisms were isolated from soil around the wild ginseng roots under forest using Esculin-R2A agar. Among these isolates, strain GS33 showed a strong ability to convert ginsenosides Rb1, Rb2, Rc, and Rd into F2, Rg3, C-K, and convert ginsenoside Rg1 into Rh1, and F1. Fermented ginseng products can inhibit ES-2 cells growth and the IC₅₀ value was 0.73 mg ml⁻¹. Phylogenetic analysis based on 16S rRNA gene sequences indicated that the strain GS33 belongs to the genus Penicillium and is most closely related to Penicillium simplicissimum (99 %).

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Year:  2014        PMID： 24122127     DOI： 10.1007/s11274-013-1520-0

Source DB:  PubMed          Journal:  World J Microbiol Biotechnol        ISSN： 0959-3993            Impact factor:   3.312


  24 in total

1.  Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells.

Authors:  Trang Thi Mai; JeongYong Moon; YeonWoo Song; Pham Quoc Viet; Pham Van Phuc; Jung Min Lee; Tae-Hoo Yi; Moonjae Cho; Somi Kim Cho
Journal:  Cancer Lett       Date:  2012-02-07       Impact factor: 8.679

2.  Microbial transformation of ginsenoside-Rg₁ by Absidia coerulea and the reversal activity of the metabolites towards multi-drug resistant tumor cells.

Authors:  Xin Liu; Lirui Qiao; Dan Xie; Yi Zhang; Jianhua Zou; Xiaoguang Chen; Jungui Dai
Journal:  Fitoterapia       Date:  2011-09-17       Impact factor: 2.882

3.  Co-transformation of Panax major ginsenosides Rb₁ and Rg₁ to minor ginsenosides C-K and F₁ by Cladosporium cladosporioides.

Authors:  Lunpeng Wu; Yan Jin; Chengri Yin; Longlv Bai
Journal:  J Ind Microbiol Biotechnol       Date:  2012-01-20       Impact factor: 3.346

4.  Ginsenoside Rh1 suppresses matrix metalloproteinase-1 expression through inhibition of activator protein-1 and mitogen-activated protein kinase signaling pathway in human hepatocellular carcinoma cells.

Authors:  Ji-Hae Yoon; Yeo-Jin Choi; Seong-Gene Lee
Journal:  Eur J Pharmacol       Date:  2012-01-31       Impact factor: 4.432

5.  Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806.

Authors:  Jingang Hou; Jianjie Xue; Chunyan Wang; Lei Liu; Dongliang Zhang; Zhen Wang; Wei Li; Yinan Zheng; Changkeun Sung
Journal:  World J Microbiol Biotechnol       Date:  2011-11-16       Impact factor: 3.312

6.  Main ginseng saponin metabolites formed by intestinal bacteria.

Authors:  H Hasegawa; J H Sung; S Matsumiya; M Uchiyama
Journal:  Planta Med       Date:  1996-10       Impact factor: 3.352

7.  Microbial conversion of major ginsenoside rb(1) to pharmaceutically active minor ginsenoside rd.

Authors:  Myung Kyum Kim; Jun Won Lee; Ki Young Lee; Deok-Chun Yang
Journal:  J Microbiol       Date:  2005-10       Impact factor: 3.422

8.  Effects of administration of the standardized Panax ginseng extract G115 on hepatic antioxidant function after exhaustive exercise.

Authors:  J Voces; A I Alvarez; L Vila; A Ferrando; C Cabral de Oliveira; J G Prieto
Journal:  Comp Biochem Physiol C Pharmacol Toxicol Endocrinol       Date:  1999-06

9.  Biotransformation of ginsenoside Rb1 to ginsenoside Rd by highly substrate-tolerant Paecilomyces bainier 229-7.

Authors:  Li Ye; Chao-Qun Zhou; Wei Zhou; Pei Zhou; Dao-Feng Chen; Xiao-Hui Liu; Xun-Long Shi; Mei-Qing Feng
Journal:  Bioresour Technol       Date:  2010-06-01       Impact factor: 9.642

Review 10.  Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer.

Authors:  Kwang-tae Choi
Journal:  Acta Pharmacol Sin       Date:  2008-09       Impact factor: 6.150
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  6 in total

1.  Study of Saponin Components after Biotransformation of Dioscorea nipponica by Endophytic Fungi C39.

Authors:  Nannan Huang; Dan Yu; Jinhai Huo; Junkai Wu; Yiyang Chen; Xiaowei Du; Xijun Wang
Journal:  J Anal Methods Chem       Date:  2022-05-11       Impact factor: 2.594

Review 2.  Recent progress in fungus-derived bioactive agents for targeting of signaling machinery in cancer cells.

Authors:  Xiukun Lin; Ammad Ahmad Farooqi; Muhammad Ismail
Journal:  Drug Des Devel Ther       Date:  2015-03-26       Impact factor: 4.162

3.  Oral administration of fermented wild ginseng ameliorates DSS-induced acute colitis by inhibiting NF-κB signaling and protects intestinal epithelial barrier.

Authors:  Myeong A Seong; Jong Kyu Woo; Ju-Hee Kang; Yeong Su Jang; Seungho Choi; Young Saeng Jang; Taek Hwan Lee; Kyung Hoon Jung; Dong Kyu Kang; Byung Seok Hurh; Dae Eung Kim; Sun Yeou Kim; Seung Hyun Oh
Journal:  BMB Rep       Date:  2015-07       Impact factor: 4.778

4.  Effects of pectin lyase-modified red ginseng extracts in high-fat diet-fed obese mice.

Authors:  Hak-Yong Lee; Kwang-Hyun Park; Young-Mi Park; Dae-In Moon; Hong-Geun Oh; Dae-Young Kwon; Hye-Jeong Yang; Okjin Kim; Dong-Woo Kim; Ji-Hyun Yoo; Se-Chul Hong; Kun-Hee Lee; Su-Yeon Seol; Yong-Sik Park; Jong-Dae Park; Mi-Kyung Pyo
Journal:  Lab Anim Res       Date:  2014-12-24

5.  Ginseng Extracts, GS-KG9 and GS-E3D, Prevent Blood-Brain Barrier Disruption and Thereby Inhibit Apoptotic Cell Death of Hippocampal Neurons in Streptozotocin-Induced Diabetic Rats.

Authors:  Jee Youn Lee; Chan Sol Park; Hae Young Choi; Tae Young Yune
Journal:  Nutrients       Date:  2020-08-09       Impact factor: 5.717

6.  Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis.

Authors:  Yan Yan; Chenhui Du; Zhenyu Li; Min Zhang; Jin Li; Jinping Jia; Aiping Li; Xuemei Qin; Qiang Song
Journal:  Chin Med       Date:  2018-10-26       Impact factor: 5.455
  6 in total

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