Literature DB >> 24121967

Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease.

Susanne J van Veluw1, Sophie M Heringa1, Hugo J Kuijf2, Huiberdina L Koek3, Peter R Luijten4, Geert Jan Biessels1.   

Abstract

Cerebral microinfarcts (CMIs) are a common finding in neuropathological studies of aging and dementia. Recently, it has become possible to detect CMIs in vivo. We studied CMI occurrence in 29 patients with mild cognitive impairment or early Alzheimer's disease (AD) and 22 non-demented individuals on 7Tesla MRI. CMI occurrence in patients (55%) and controls (45%) was not significantly different. In patients, CMI number tended to be related to microbleed number (p = 0.07). This first in vivo study of CMIs in early AD does not confirm findings from autopsy studies. Further studies are needed to clarify the role of CMIs in AD.

Entities:  

Keywords:  Alzheimer's disease; magnetic resonance imaging; microbleeds; microinfarcts; mild cognitive impairment

Mesh：

Year:  2014        PMID： 24121967     DOI： 10.3233/JAD-131040

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  16 in total

1.  The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations.

Authors:  E Cavedo; S Lista; Z Khachaturian; P Aisen; P Amouyel; K Herholz; C R Jack; R Sperling; J Cummings; K Blennow; S O'Bryant; G B Frisoni; A Khachaturian; M Kivipelto; W Klunk; K Broich; S Andrieu; M Thiebaut de Schotten; J-F Mangin; A A Lammertsma; K Johnson; S Teipel; A Drzezga; A Bokde; O Colliot; H Bakardjian; H Zetterberg; B Dubois; B Vellas; L S Schneider; H Hampel
Journal:  J Prev Alzheimers Dis       Date:  2014-12

Review 2.  Magnetic resonance imaging at ultrahigh fields.

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3.  Cortical microinfarcts on 7T MRI in patients with spontaneous intracerebral hemorrhage.

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Journal:  J Cereb Blood Flow Metab       Date:  2014-04-23       Impact factor: 6.200

4.  The spectrum of MR detectable cortical microinfarcts: a classification study with 7-tesla postmortem MRI and histopathology.

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Review 8.  Prevalence of Brain Microbleeds in Alzheimer Disease: A Systematic Review and Meta-Analysis on the Influence of Neuroimaging Techniques.

Authors:  A A Sepehry; D Lang; G-Y Hsiung; A Rauscher
Journal:  AJNR Am J Neuroradiol       Date:  2015-12-03       Impact factor: 3.825

Review 9.  Detection, risk factors, and functional consequences of cerebral microinfarcts.

Authors:  Susanne J van Veluw; Andy Y Shih; Eric E Smith; Christopher Chen; Julie A Schneider; Joanna M Wardlaw; Steven M Greenberg; Geert Jan Biessels
Journal:  Lancet Neurol       Date:  2017-07-14       Impact factor: 44.182

10.  Cerebral Cortical Microinfarcts on Magnetic Resonance Imaging and Their Association With Cognition in Cerebral Amyloid Angiopathy.

Authors:  Li Xiong; Susanne J van Veluw; Narimene Bounemia; Andreas Charidimou; Marco Pasi; Gregoire Boulouis; Yael D Reijmer; Anne-Katrin Giese; Sigurros Davidsdottir; Panagiotis Fotiadis; Raffaella Valenti; Grace Riley; Kristin Schwab; Edip M Gurol; Alessandro Biffi; Steven M Greenberg; Anand Viswanathan
Journal:  Stroke       Date:  2018-10       Impact factor: 7.914
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