Literature DB >> 2412065

Two classes of myocardial 5-hydroxytryptamine receptors that are neither 5-HT1 nor 5-HT2.

A J Kaumann.   

Abstract

5-Hydroxytryptamine (5-HT) increases the sinoatrial beating rate and the force of contraction of paced left atria and papillary muscles (right ventricle) of the kitten. These effects of 5-HT are evident in tissues from noradrenaline-depleted kittens (reserpine pretreatment), and therefore elicited through myocardial 5-HT receptors. The atrial and ventricular effects of 5-HT were unaffected by concentrations of 8-OH DPAT and ketanserin saturating 5-HT1 and 5-HT2 receptors, respectively. Phenoxybenzamine blocked irreversibly sinoatrial and left atrial effects of 5-HT but not the effects of 5-HT on ventricular muscle. 5-Hydroxytryptamine causes prolongation of the ventricular action potential. Sinoatrial and left atrial 5-HT receptors are coined 5-HT3 and ventricular receptors are coined 5-HT4.

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Year:  1985        PMID： 2412065     DOI： 10.1097/00005344-198500077-00022

Source DB:  PubMed          Journal:  J Cardiovasc Pharmacol        ISSN： 0160-2446            Impact factor:   3.105


  7 in total

1.  Evidence for inhibition by ICS 205-930 and stimulation by BRL 34915 of K+ conductance in cardiac muscle.

Authors:  G Scholtysik
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-06       Impact factor: 3.000

2.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

3.  A 5-hydroxytryptamine receptor in human atrium.

Authors:  A J Kaumann; L Sanders; A M Brown; K J Murray; M J Brown
Journal:  Br J Pharmacol       Date:  1990-08       Impact factor: 8.739

4.  Diverse inotropic effects of 5-hydroxytryptamine in heart muscles of various mammalian species.

Authors:  H Zaizen; S Imanishi; M Nasu; M Arita
Journal:  Heart Vessels       Date:  1996       Impact factor: 2.037

5.  5-Hydroxytryptamine-induced tachycardia in the pig: possible involvement of a new type of 5-hydroxytryptamine receptor.

Authors:  A H Bom; D J Duncker; P R Saxena; P D Verdouw
Journal:  Br J Pharmacol       Date:  1988-03       Impact factor: 8.739

6.  Reflex inhibition of efferent renal sympathetic nerve activity by 5-hydroxytryptamine and nicotine is elicited by different epicardial receptors.

Authors:  B Mohr; A H Bom; A J Kaumann; V Thämer
Journal:  Pflugers Arch       Date:  1987-06       Impact factor: 3.657

7.  Reduction of cephalic arteriovenous shunting by ergotamine is not mediated by 5-HT1-like or 5-HT2 receptors.

Authors:  A H Bom; J P Heiligers; P R Saxena; P D Verdouw
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739
  7 in total

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