| Literature DB >> 24120543 |
Zhen-Wei Wu1, Hai-Wei Xu, Gui-Fu Dai, Meng-Jiao Liu, Li-Ping Zhu, Jian Wu, Ya-Nan Wang, Feng-Juan Wu, Dan Zhao, Ming-Fu Gao, Shan-Shan Nie, Wei Han, Jing-Hui Song, Hong-Min Liu.
Abstract
In the present study, andrographolide (Andro, 1) derivatives were screened to identify potent inhibitors against tumor-cell migration and invasion, and associated structure-activity relationships were studied. Compared to 1, compounds 8a-8d exhibited more potent activities against migration in SGC-7901, PC-3, A549, HT-29 and Ec109 cell lines. Improved activities against tumor-cell migration and invasion were proved to be associated with the down-regulation of MMPs.Entities:
Keywords: Andrographolide; Derivative; Invasion; MMP-9; Migration
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Year: 2013 PMID： 24120543 DOI： 10.1016/j.bmcl.2013.09.049
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823