| Literature DB >> 24120298 |
Emanuela Giacomelli1, Samuel Bertrand, Andreas Nievergelt, Vincent Zwick, Claudia Simoes-Pires, Laurence Marcourt, Elisabeth Rivara-Minten, Muriel Cuendet, Angela Bisio, Jean-Luc Wolfender.
Abstract
NMR and NP-HPLC-UV profiling of the exudate of Salvia corrugata revealed that its secondary metabolite composition was largely dominated by α-hydroxy-β-isopropyl-benzoquinone diterpenoids. Among them, four diterpenes not described previously were isolated and identified as fruticulin C (3), 7α-methoxy-19-acetoxy-royleanone (4), 7α,19-diacetoxy-royleanone (5), and 7-dehydroxy-conacytone (7). In addition, the known diterpenes fruticulin A (1), demethyl-fruticulin A (2) and 7α-O-methyl-conacytone (6) were also obtained. The isolated compounds were evaluated for their cancer chemopreventive activity by measuring quinone reductase induction activity and histone deacetylase inhibition. Three compounds (1, 2 and 5) showed promising activity.Entities:
Keywords: Abietane; Diterpenes; Fruticulin C; Histone deacetylase; Icetexane; Quinone reductase; Salvia corrugata
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Year: 2013 PMID： 24120298 DOI： 10.1016/j.phytochem.2013.09.011
Source DB: PubMed Journal: Phytochemistry ISSN： 0031-9422 Impact factor: 4.072