Tzu-Hsien Lai1, Ren-Shyan Liu, Bang-Hung Yang, Po-Shan Wang, Kon-Ping Lin, Yi-Chung Lee, Bing-Wen Soong. 1. Department of Neurology, National Yang-Ming University, Taipei, Taiwan; Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan; Division of Neurology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Neurology, Taipei Veterans General Hospital, Taipei, Taiwan.
Abstract
OBJECTIVE: To investigate possible cerebral involvement in patients with spinal and bulbar muscular atrophy (SBMA) by (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET). DESIGN: Ten patients with molecularly-confirmed SBMA and 5 age- and gender-matched healthy controls were recruited for brain FDG-PET studies. The data were analyzed and compared using the statistical parametric mapping (SPM) method. RESULTS: Glucose hypometabolism in frontal areas of the cerebrum was found in patients with SBMA. However, no significant correlation with clinical variables, such as CAG repeat length, age at onset, or serum testosterone levels, was noted. CONCLUSIONS: The perturbation of cerebral glucose metabolism in patients with SBMA argues against SBMA being a pure lower motor and sensory neuron syndrome. Mutations in the androgen receptor gene might have a more widespread effect in the cerebrum than previously recognized.
OBJECTIVE: To investigate possible cerebral involvement in patients with spinal and bulbar muscular atrophy (SBMA) by (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET). DESIGN: Ten patients with molecularly-confirmed SBMA and 5 age- and gender-matched healthy controls were recruited for brain FDG-PET studies. The data were analyzed and compared using the statistical parametric mapping (SPM) method. RESULTS:Glucose hypometabolism in frontal areas of the cerebrum was found in patients with SBMA. However, no significant correlation with clinical variables, such as CAG repeat length, age at onset, or serum testosterone levels, was noted. CONCLUSIONS: The perturbation of cerebral glucose metabolism in patients with SBMA argues against SBMA being a pure lower motor and sensory neuron syndrome. Mutations in the androgen receptor gene might have a more widespread effect in the cerebrum than previously recognized.
Authors: Donatienne Van Weehaeghe; Martijn Devrome; Michel Koole; Koen Van Laere; Georg Schramm; Joke De Vocht; Wies Deckers; Kristof Baete; Philip Van Damme Journal: Eur J Nucl Med Mol Imaging Date: 2020-04-20 Impact factor: 9.236
Authors: S Marcato; J R Kleinbub; G Querin; E Pick; I Martinelli; C Bertolin; S Cipolletta; E Pegoraro; G Sorarù; A Palmieri Journal: Sci Rep Date: 2018-09-11 Impact factor: 4.379