Literature DB >> 24119491

A new way to treat forearm post-traumatic non-union in young patients with intramedullary nailing and platelet-rich plasma.

A Memeo1, F Verdoni1, O De Bartolomeo2, W Albisetti3, L Pedretti4.   

Abstract

INTRODUCTION: Non-union rate in forearm fractures is generally less than 2% when a proper technique is used; this rate increases when ulnar lesions are involved. PATIENTS AND METHODS: We present a case series of seven young patients whose average age was 14 years (range 11-19 years) at the time of surgery and who presented with a forearm post-traumatic non-union that was previously treated in different ways (three isolated ulnar non-union, two isolated radial non-union and two combined). Average follow-up was 34 months (range 9-72 months). Surgical treatment began with the removal of the previous synthesis and with curettage of the non-union area. The Acumed ulnar rod, Acumed radial rod and Thalon elastic nail (all of them are unreamed and locked nails) together with autologous platelet-rich plasma (PRP) obtained with the Biomet System (concentration of 158.2×10(4) platelets/μL) were chosen to treat the patients. X-rays and clinical controls were conducted every 30 days until recovery.
RESULTS: All patients recovered: average recovery was 23 weeks from operation (range 16-36 weeks) and nails were removed 3 months after complete healing. Six patients had excellent results and one patient had a good result (Patient 2, forearm pronosupination 60-0-40 degrees). DISCUSSION: The purpose of the case series was to establish a better way of treatment and to find a technique that could avoid the use of bone grafts, because obtaining autologous bone requires a further surgical procedure that can be really invasive depending on the amount of bone needed.
CONCLUSION: All patients in the study showed complete recovery, with excellent clinical outcomes. Although there were only seven patients in this case series, and there is a need to analyse more patients, this study showed that the use of a specific locking nail system can provide proper stability to ulnar or radial atrophic non-union despite rotational forces, and when combined with autologous growth factors (PRP) is sufficient to promote bone healing in young patients without the necessity to take autologous bone grafts.
Copyright © 2013 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Forearm; Intramedullary nail; Locked; Non-union; Platelet-rich plasma; Post-traumatic; Radial; Ulnar

Mesh:

Substances:

Year:  2013        PMID: 24119491     DOI: 10.1016/j.injury.2013.09.021

Source DB:  PubMed          Journal:  Injury        ISSN: 0020-1383            Impact factor:   2.586


  8 in total

1.  Treatment of nonunion after forearm fractures in children: a conservative approach.

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2.  Effects of Platelet Rich Plasma on Healing Rate of Long Bone Non-union Fractures: A Randomized Double-Blind Placebo Controlled Clinical Trial.

Authors:  Fariborz Ghaffarpasand; Mostafa Shahrezaei; Maryam Dehghankhalili
Journal:  Bull Emerg Trauma       Date:  2016-07

Review 3.  The role of peptides in bone healing and regeneration: a systematic review.

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Journal:  BMC Med       Date:  2016-07-11       Impact factor: 8.775

4.  Advantages of pure platelet-rich plasma compared with leukocyte- and platelet-rich plasma in promoting repair of bone defects.

Authors:  Wenjing Yin; Xin Qi; Yuelei Zhang; Jiagen Sheng; Zhengliang Xu; Shicong Tao; Xuetao Xie; Xiaolin Li; Changqing Zhang
Journal:  J Transl Med       Date:  2016-03-15       Impact factor: 5.531

5.  Autologous platelet lysates local injections for treatment of tibia non-union with breakage of the nickelclad: a case report.

Authors:  Hong-Jiang Jiang; Xun-Xiang Tan; Hai-Yang Ju; Jin-Ping Su; Wei Yan; Xiu-Gang Song; Li-Wu Qin; Chang-Jun Ju; Ling-Shuang Wang; De-Bao Zou
Journal:  Springerplus       Date:  2016-11-25

6.  The Effect of Smoking on Posttraumatic Pseudoarthrosis Healing after Internal Stabilization, Treated with Platelet Rich Plasma (PRP).

Authors:  Michał Wechmann; Paweł Ziętek; Łukasz Sieczka; Konrad Dobiecki; Joanna Krzywda-Pogorzelska; Radomir Czajka; Adam Kamiński; Andrzej Bohatyrewicz; Daniel Kotrych
Journal:  Open Med (Wars)       Date:  2018-09-21

7.  Percutaneous injection of platelet-rich plasma to treat atrophic nonunion after internal fixation of ulnar fracture: a case report.

Authors:  Shao-Guang Li; Yong Huang; Hai-Jia Zhu; Jie-Feng Huang
Journal:  Nagoya J Med Sci       Date:  2021-02       Impact factor: 1.131

8.  Clinical Effectiveness of Platelet-Rich Plasma for Long-Bone Delayed Union and Nonunion: A Systematic Review and Meta-Analysis.

Authors:  Shang Li; Fei Xing; Rong Luo; Ming Liu
Journal:  Front Med (Lausanne)       Date:  2022-01-25
  8 in total

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