BACKGROUND: Topical photodynamic therapy (PDT) is an option for the treatment of cutaneous malignancy. OBJECTIVE: To present an update and expansion on a previous review of the use of PDT in the current literature in the treatment of actinic keratoses (AK), superficial and nodular basal cell carcinoma (sBCC, nBCC), squamous cell carcinoma (SCC), Bowen's disease, cutaneous T cell lymphoma (CTCL), malignant melanoma, and its use in chemoprevention. METHODS: Extensive PubMed search January 2013. RESULTS AND CONCLUSIONS: We find sufficient evidence to recommend the use of PDT in certain patients in the treatment of AK, Bowen's disease, sBCC, and nBCC. It is especially useful in those with contraindications to surgery, widespread areas of involvement, and large lesions. Not only can it be considered superior to other therapies as far as recovery time, tolerance, and cosmetic outcomes, but it also should be considered, when indicated, as first-line treatment in the above conditions. Investigations continue for the use of PDT in the treatment of melanoma, SCC, chemoprevention, and CTCL.
BACKGROUND: Topical photodynamic therapy (PDT) is an option for the treatment of cutaneous malignancy. OBJECTIVE: To present an update and expansion on a previous review of the use of PDT in the current literature in the treatment of actinic keratoses (AK), superficial and nodular basal cell carcinoma (sBCC, nBCC), squamous cell carcinoma (SCC), Bowen's disease, cutaneous T cell lymphoma (CTCL), malignant melanoma, and its use in chemoprevention. METHODS: Extensive PubMed search January 2013. RESULTS AND CONCLUSIONS: We find sufficient evidence to recommend the use of PDT in certain patients in the treatment of AK, Bowen's disease, sBCC, and nBCC. It is especially useful in those with contraindications to surgery, widespread areas of involvement, and large lesions. Not only can it be considered superior to other therapies as far as recovery time, tolerance, and cosmetic outcomes, but it also should be considered, when indicated, as first-line treatment in the above conditions. Investigations continue for the use of PDT in the treatment of melanoma, SCC, chemoprevention, and CTCL.
Authors: Simon Y Kimm; Tatum V Tarin; Sébastien Monette; Govindarajan Srimathveeravalli; Daniel Gerber; Jeremy C Durack; Stephen B Solomon; Peter T Scardino; Avigdor Scherz; Jonathan Coleman Journal: Radiology Date: 2016-03-17 Impact factor: 11.105
Authors: Ahtasham Raza; Stuart A Archer; Simon D Fairbanks; Kirsty L Smitten; Stanley W Botchway; James A Thomas; Sheila MacNeil; John W Haycock Journal: J Am Chem Soc Date: 2020-02-25 Impact factor: 15.419