Literature DB >> 2411720

Inhibitory effects of 9-beta-D-xylofuranosyladenine 5'-triphosphate on DNA-dependent RNA polymerase I and II from cherry salmon (Oncorhynchus masou).

C Nakayama, M Saneyoshi.   

Abstract

In order to determine the mode of action of cytostatic 9-beta-D-xylofuranosyladenine (xylo-A), the inhibitory effects of 9-beta-D-xylofuranosyladenine 5'-triphosphate (xylo-ATP) on DNA-dependent RNA polymerases I and II purified from cherry salmon (Oncorhynchus masou) liver nuclei were studied. This nucleotide showed strong inhibitory action on both RNA polymerases I and II. The K1 values are 14 microM for polymerase I and 5 microM for polymerase II (Km values of ATP are 37 microM for polymerase I and 40 microM for polymerase II). The mode of xylo-ATP was competitive with respect to the incorporation of AMP into RNA and non-competitive to UTP and CTP.

Entities:  

Mesh：

Substances：

Year:  1985        PMID： 2411720     DOI： 10.1093/oxfordjournals.jbchem.a135192

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  9 in total

1.  Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase.

Authors:  Y Mizushina; A Iida; K Ohta; F Sugawara; K Sakaguchi
Journal:  Biochem J       Date:  2000-09-15       Impact factor: 3.857

2.  Purified canola lutein selectively inhibits specific isoforms of mammalian DNA polymerases and reduces inflammatory response.

Authors:  Sho Horie; Chiaki Okuda; Takatoshi Yamashita; Kenichi Watanabe; Kouji Kuramochi; Masashi Hosokawa; Toshifumi Takeuchi; Makiko Kakuda; Kazuo Miyashita; Fumio Sugawara; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Lipids       Date:  2010-07-29       Impact factor: 1.880

3.  Inhibitory action of emulsified sulfoquinovosyl acylglycerol on mammalian DNA polymerases.

Authors:  Yoshiyuki Mizushina; Naoki Maeda; Miho Kawasaki; Hideki Ichikawa; Chikako Murakami; Masaharu Takemura; Xianai Xu; Fumio Sugawara; Yoshinobu Fukumori; Hiromi Yoshida; Kengo Sakaguchi
Journal:  Lipids       Date:  2003-10       Impact factor: 1.880

4.  Inhibitory effects of cholesterol derivatives on DNA polymerase and topoisomerase activities, and human cancer cell growth.

Authors:  Chisato Ishimaru; Yuko Yonezawa; Isoko Kuriyama; Masayuki Nishida; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  Lipids       Date:  2008-01-24       Impact factor: 1.880

5.  Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases.

Authors:  Yoshiyuki Mizushina; Jinhui Zhang; Angelo Pugliese; Sung-Hoon Kim; Junxuan Lü
Journal:  Biochem Pharmacol       Date:  2010-06-26       Impact factor: 6.100

6.  Structure-activity relationship of a novel group of mammalian DNA polymerase inhibitors, synthetic sulfoquinovosylacylglycerols.

Authors:  S Hanashima; Y Mizushina; K Ohta; T Yamazaki; F Sugawara; K Sakaguchi
Journal:  Jpn J Cancer Res       Date:  2000-10

7.  3-O-methylfunicone, a selective inhibitor of mammalian Y-family DNA polymerases from an Australian sea salt fungal strain.

Authors:  Yoshiyuki Mizushina; Hirohisa Motoshima; Yasuhiro Yamaguchi; Toshifumi Takeuchi; Ken Hirano; Fumio Sugawara; Hiromi Yoshida
Journal:  Mar Drugs       Date:  2009-11-23       Impact factor: 5.118

8.  Anti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activity.

Authors:  Moe Kawamura; Isoko Kuriyama; Sayako Maruo; Kouji Kuramochi; Kazunori Tsubaki; Hiromi Yoshida; Yoshiyuki Mizushina
Journal:  PLoS One       Date:  2014-02-10       Impact factor: 3.240

9.  The inhibitory action of kohamaic acid A derivatives on mammalian DNA polymerase beta.

Authors:  Yoshiyuki Mizushina; Daisuke Manita; Toshifumi Takeuchi; Fumio Sugawara; Yuko Kumamoto-Yonezawa; Yuki Matsui; Masaharu Takemura; Mitsuru Sasaki; Hiromi Yoshida; Hirosato Takikawa
Journal:  Molecules       Date:  2008-12-29       Impact factor: 4.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.