Literature DB >> 24117139

Rethinking antioxidants in the intensive care unit.

Manu Jain1, Navdeep S Chandel.   

Abstract

Recently there was yet another clinical trial using antioxidants that failed in patients with critical illness. In this perspective, we suggest that antioxidants likely interfere with the normal immune response, thus contributing to the lack of efficacy in patients with critical illness.

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Year:  2013        PMID： 24117139      PMCID： PMC3919077          DOI： 10.1164/rccm.201307-1380CP

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN： 1073-449X            Impact factor:   21.405


  31 in total

1.  Oxidant activity in expired breath of patients with adult respiratory distress syndrome.

Authors:  S R Baldwin; R H Simon; C M Grum; L H Ketai; L A Boxer; L J Devall
Journal:  Lancet       Date:  1986-01-04       Impact factor: 79.321

2.  Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling.

Authors:  Laura A Sena; Sha Li; Amit Jairaman; Murali Prakriya; Teresa Ezponda; David A Hildeman; Chyung-Ru Wang; Paul T Schumacker; Jonathan D Licht; Harris Perlman; Paul J Bryce; Navdeep S Chandel
Journal:  Immunity       Date:  2013-02-15       Impact factor: 31.745

Review 3.  Taking a "good" look at free radicals in the aging process.

Authors:  Siegfried Hekimi; Jérôme Lapointe; Yang Wen
Journal:  Trends Cell Biol       Date:  2011-08-06       Impact factor: 20.808

Review 4.  From sulfenylation to sulfhydration: what a thiolate needs to tolerate.

Authors:  Toren Finkel
Journal:  Sci Signal       Date:  2012-03-13       Impact factor: 8.192

Review 5.  Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach.

Authors:  Richard S Hotchkiss; Guillaume Monneret; Didier Payen
Journal:  Lancet Infect Dis       Date:  2013-03       Impact factor: 25.071

6.  A randomized trial of glutamine and antioxidants in critically ill patients.

Authors:  Daren Heyland; John Muscedere; Paul E Wischmeyer; Deborah Cook; Gwynne Jones; Martin Albert; Gunnar Elke; Mette M Berger; Andrew G Day
Journal:  N Engl J Med       Date:  2013-04-18       Impact factor: 91.245

Review 7.  Metabolic pathways in immune cell activation and quiescence.

Authors:  Erika L Pearce; Edward J Pearce
Journal:  Immunity       Date:  2013-04-18       Impact factor: 31.745

Review 8.  Physiological roles of mitochondrial reactive oxygen species.

Authors:  Laura A Sena; Navdeep S Chandel
Journal:  Mol Cell       Date:  2012-10-26       Impact factor: 17.970

Review 9.  Regulation of innate immunity by NADPH oxidase.

Authors:  Brahm H Segal; Melissa J Grimm; A Nazmul H Khan; Wei Han; Timothy S Blackwell
Journal:  Free Radic Biol Med       Date:  2012-05-01       Impact factor: 7.376

Review 10.  N-acetylcysteine for sepsis and systemic inflammatory response in adults.

Authors:  Tamas Szakmany; Balázs Hauser; Peter Radermacher
Journal:  Cochrane Database Syst Rev       Date:  2012-09-12
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  13 in total

1.  Antioxidants in the intensive care unit.

Authors:  Aron B Fisher; Henry Jay Forman
Journal:  Am J Respir Crit Care Med       Date:  2014-04-15       Impact factor: 21.405

Review 2.  [Cardioprotection in cardiac surgical patients : Everything good comes from the heart].

Authors:  C Stoppe; P Meybohm; M Coburn; A Goetzenich
Journal:  Anaesthesist       Date:  2016-03       Impact factor: 1.041

Review 3.  Immunometabolism of pro-repair cells.

Authors:  Benjamin D Singer; Navdeep S Chandel
Journal:  J Clin Invest       Date:  2019-05-13       Impact factor: 14.808

4.  Gut-origin sepsis in the critically ill patient: pathophysiology and treatment.

Authors:  Stelios F Assimakopoulos; Christos Triantos; Konstantinos Thomopoulos; Fotini Fligou; Ioannis Maroulis; Markos Marangos; Charalambos A Gogos
Journal:  Infection       Date:  2018-07-12       Impact factor: 3.553

5.  Differential acute effects of selenomethionine and sodium selenite on the severity of colitis.

Authors:  Franziska Hiller; Lisa Oldorff; Karolin Besselt; Anna Patricia Kipp
Journal:  Nutrients       Date:  2015-04-10       Impact factor: 5.717

6.  Antioxidant activity of pomegranate juice reduces emphysematous changes and injury secondary to cigarette smoke in an animal model and human alveolar cells.

Authors:  Ahmad Husari; Yasmine Hashem; Hala Bitar; Ghassan Dbaibo; Ghazi Zaatari; Marwan El Sabban
Journal:  Int J Chron Obstruct Pulmon Dis       Date:  2016-02-03

7.  Nuclear Thioredoxin-1 Overexpression Attenuates Alcohol-Mediated Nrf2 Signaling and Lung Fibrosis.

Authors:  Viranuj Sueblinvong; Stephen T Mills; David C Neujahr; Young-Mi Go; Dean P Jones; David M Guidot
Journal:  Alcohol Clin Exp Res       Date:  2016-07-20       Impact factor: 3.455

8.  Effects of N-acetylcysteine treatment in acute respiratory distress syndrome: A meta-analysis.

Authors:  Ying Zhang; Shaoxue Ding; Caifeng Li; Yifeng Wang; Zhe Chen; Zhiqiang Wang
Journal:  Exp Ther Med       Date:  2017-08-07       Impact factor: 2.447

Review 9.  Endoplasmic Reticulum Stress and Mitochondrial Function in Airway Smooth Muscle.

Authors:  Philippe Delmotte; Gary C Sieck
Journal:  Front Cell Dev Biol       Date:  2020-01-15

10.  Antioxidant activity of pomegranate juice reduces acute lung injury secondary to hyperoxia in an animal model.

Authors:  Ahmad Husari; Aline Khayat; Hala Bitar; Yasmine Hashem; Alain Rizkallah; Ghazi Zaatari; Marwan El Sabban
Journal:  BMC Res Notes       Date:  2014-09-21
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