BACKGROUND: The association of age-related cognitive change with hospitalization is not well understood. METHODS: At 3-year intervals for a mean of 8.7 years, 2,273 older residents of a geographically defined urban community underwent cognitive testing from which a global measure was derived. Hospitalization data were obtained from Part A Medicare beneficiary records. The association of level of cognitive function and rate of cognitive decline in each 3-year interval with subsequent rate of hospitalization was assessed using mixed-effects count regression models. RESULTS: There were 9,091 hospitalizations involving 1,810 of the 2,273 individuals in the cohort (79.6%). Rate of hospitalization increased by 9.7% (95% confidence interval [CI]: 7.2, 12.3) with each additional study year; by 32.7% (95% CI: 26.8, 38.0) for each 1 point lower on the global cognitive measure at the beginning of an observation interval; and by 24.3% (95% CI: 16.6, 32.6) for each 1-point decrease in the global cognitive measure during the previous observation period. These associations persisted after adjustment for comorbidities and exclusion of those with a Mini-Mental State Examination score less than 26. CONCLUSION: Individual differences in trajectories of cognitive aging are associated with subsequent risk of hospitalization.
BACKGROUND: The association of age-related cognitive change with hospitalization is not well understood. METHODS: At 3-year intervals for a mean of 8.7 years, 2,273 older residents of a geographically defined urban community underwent cognitive testing from which a global measure was derived. Hospitalization data were obtained from Part A Medicare beneficiary records. The association of level of cognitive function and rate of cognitive decline in each 3-year interval with subsequent rate of hospitalization was assessed using mixed-effects count regression models. RESULTS: There were 9,091 hospitalizations involving 1,810 of the 2,273 individuals in the cohort (79.6%). Rate of hospitalization increased by 9.7% (95% confidence interval [CI]: 7.2, 12.3) with each additional study year; by 32.7% (95% CI: 26.8, 38.0) for each 1 point lower on the global cognitive measure at the beginning of an observation interval; and by 24.3% (95% CI: 16.6, 32.6) for each 1-point decrease in the global cognitive measure during the previous observation period. These associations persisted after adjustment for comorbidities and exclusion of those with a Mini-Mental State Examination score less than 26. CONCLUSION: Individual differences in trajectories of cognitive aging are associated with subsequent risk of hospitalization.
Entities:
Keywords:
Cognitive aging; Epidemiology; Hospital related; Public health.
Authors: R S Wilson; D A Bennett; J L Bienias; N T Aggarwal; C F Mendes De Leon; M C Morris; J A Schneider; D A Evans Journal: Neurology Date: 2002-12-24 Impact factor: 9.910
Authors: Oscar L Lopez; William J Jagust; Steven T DeKosky; James T Becker; Annette Fitzpatrick; Corinne Dulberg; John Breitner; Constantine Lyketsos; Beverly Jones; Claudia Kawas; Michelle Carlson; Lewis H Kuller Journal: Arch Neurol Date: 2003-10
Authors: Joshua Chodosh; Teresa E Seeman; Emmett Keeler; Ase Sewall; Susan H Hirsch; Jack M Guralnik; David B Reuben Journal: J Am Geriatr Soc Date: 2004-09 Impact factor: 5.562
Authors: R S Wilson; C F Mendes De Leon; D A Bennett; J L Bienias; D A Evans Journal: J Neurol Neurosurg Psychiatry Date: 2004-01 Impact factor: 10.154
Authors: Robert S Wilson; Lei Yu; John Q Trojanowski; Er-Yun Chen; Patricia A Boyle; David A Bennett; Julie A Schneider Journal: JAMA Neurol Date: 2013-11 Impact factor: 18.302
Authors: Julia L Bienias; Laurel A Beckett; David A Bennett; Robert S Wilson; Denis A Evans Journal: J Alzheimers Dis Date: 2003-10 Impact factor: 4.472
Authors: Robert S Wilson; Kumar B Rajan; Lisa L Barnes; Willemijn Jansen; Priscilla Amofa; Jennifer Weuve; Denis A Evans Journal: Neuropsychol Dev Cogn B Aging Neuropsychol Cogn Date: 2017-03-23
Authors: Kristine E Ensrud; Li-Yung Lui; Misti L Paudel; John T Schousboe; Allyson M Kats; Jane A Cauley; Charles E McCulloch; Kristine Yaffe; Peggy M Cawthon; Teresa A Hillier; Brent C Taylor Journal: J Gerontol A Biol Sci Med Sci Date: 2017-01-01 Impact factor: 6.053
Authors: Kristine E Ensrud; Li-Yung Lui; Lisa Langsetmo; Tien N Vo; Brent C Taylor; Peggy M Cawthon; Meredith L Kilgore; Charles E McCulloch; Jane A Cauley; Marcia L Stefanick; Kristine Yaffe; Eric S Orwoll; John T Schousboe Journal: J Gerontol A Biol Sci Med Sci Date: 2018-09-11 Impact factor: 6.053
Authors: Bryan D James; Robert S Wilson; Ana W Capuano; Patricia A Boyle; Raj C Shah; Melissa Lamar; E Wesley Ely; David A Bennett; Julie A Schneider Journal: Ann Neurol Date: 2019-10-23 Impact factor: 10.422
Authors: Klodian Dhana; Lisa L Barnes; Xiaoran Liu; Puja Agarwal; Pankaja Desai; Kristin R Krueger; Thomas M Holland; Shannon Halloway; Neelum T Aggarwal; Denis A Evans; Kumar B Rajan Journal: Alzheimers Dement Date: 2021-07-26 Impact factor: 16.655