BACKGROUND: Granuloma of the upper aerodigestive tract is a rare presentation of immunoglobulin-G4 (IgG4)-related disease. Since the disease process was defined in 2003, only 2 cases affecting the laryngopharynx have been reported in the literature. METHODS AND RESULTS: A 62-year-old white man presented with persistent productive cough of brown sputum, globus symptoms, dysphagia, odynophagia, dysphonia, otalgia, and general malaise over a period of 2 months. Investigations revealed IgG4-positive plasma cell granuloma of the supraglottic region. This was successfully treated with oral corticosteroids. CONCLUSION: Because IgG4 testing is not performed routinely, management recommendations have been poorly defined. We reviewed the literature and discuss herein the clinical characteristics, pathology, diagnosis, and management. The authors theorize that IgG4-related disease involving the larynx and pharynx may be more common than suggested by the paucity of reported cases.
BACKGROUND:Granuloma of the upper aerodigestive tract is a rare presentation of immunoglobulin-G4 (IgG4)-related disease. Since the disease process was defined in 2003, only 2 cases affecting the laryngopharynx have been reported in the literature. METHODS AND RESULTS: A 62-year-old white man presented with persistent productive cough of brown sputum, globus symptoms, dysphagia, odynophagia, dysphonia, otalgia, and general malaise over a period of 2 months. Investigations revealed IgG4-positive plasma cell granuloma of the supraglottic region. This was successfully treated with oral corticosteroids. CONCLUSION: Because IgG4 testing is not performed routinely, management recommendations have been poorly defined. We reviewed the literature and discuss herein the clinical characteristics, pathology, diagnosis, and management. The authors theorize that IgG4-related disease involving the larynx and pharynx may be more common than suggested by the paucity of reported cases.
Authors: Ádám Bach; Andrea Ambrus; Béla Iványi; Zoltán Tóbiás; Gholam Hossein Alim Marvasti; László Rovó Journal: Iran J Otorhinolaryngol Date: 2021-03
Authors: Belén Atienza-Mateo; Teresa Díaz de Terán-López; Javier Gómez-Román; Laura Sánchez; Roberto Mons-Lera; Antonio Rubio-Suárez; José Manuel Cifrián; Miguel Á González-Gay Journal: Rheumatol Int Date: 2021-04-08 Impact factor: 2.631
Authors: Elizabeth F Maughan; Joshua Michaels; Benjamin Miller; Justin Weir; Alan Salama; Elinor Warner; Khalid Ghufoor; Gurpreet Sandhu; Chadwan Al Yaghchi Journal: Clin Med Insights Case Rep Date: 2020-10-28