Literature DB >> 24115355

End-to-end continuous manufacturing of pharmaceuticals: integrated synthesis, purification, and final dosage formation.

Salvatore Mascia1, Patrick L Heider, Haitao Zhang, Richard Lakerveld, Brahim Benyahia, Paul I Barton, Richard D Braatz, Charles L Cooney, James M B Evans, Timothy F Jamison, Klavs F Jensen, Allan S Myerson, Bernhardt L Trout.   

Abstract

A series of tubes: The continuous manufacture of a finished drug product starting from chemical intermediates is reported. The continuous pilot-scale plant used a novel route that incorporated many advantages of continuous-flow processes to produce active pharmaceutical ingredients and the drug product in one integrated system.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords:  continuous processing; flow chemistry; lactones; protecting groups; synthetic methods

Mesh：

Substances：

Year:  2013        PMID： 24115355     DOI： 10.1002/anie.201305429

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  32 in total

1.  Advancing Product Quality: a Summary of the Second FDA/PQRI Conference.

Authors:  Lawrence X Yu; Ilgaz Akseli; Barbara Allen; Gregory Amidon; Tara Gooen Bizjak; Ashley Boam; Margaret Caulk; David Doleski; Joseph Famulare; Adam C Fisher; Scott Furness; Brian Hasselbalch; Henry Havel; Stephen W Hoag; Robert Iser; Bruce D Johnson; Robert Ju; Paula Katz; Emanuela Lacana; Sau L Lee; Richard Lostritto; Grace McNally; Mehul Mehta; Ganapathy Mohan; Moheb Nasr; Roger Nosal; Mary Oates; Thomas O'Connor; Jim Polli; G K Raju; Mahesh Ramanadham; Giuseppe Randazzo; Susan Rosencrance; Anna Schwendeman; Arzu Selen; Paul Seo; Vinod Shah; Ramesh Sood; Michael P Thien; Tony Tong; Bernhardt L Trout; Katherine Tyner; Siva Vaithiyalingam; Martin VanTrieste; Fionnuala Walsh; Russell Wesdyk; Janet Woodcock; Geoffrey Wu; Larisa Wu; Louis Yu; Diane Zezza
Journal:  AAPS J       Date:  2016-02-09       Impact factor: 4.009

2.  Organic synthesis: The robo-chemist.

Authors:  Mark Peplow
Journal:  Nature       Date:  2014-08-07       Impact factor: 49.962

Review 3.  The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.

Authors:  Melanie Trobe; Martin D Burke
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-07       Impact factor: 15.336

4.  The assembly and use of continuous flow systems for chemical synthesis.

Authors:  Joshua Britton; Timothy F Jamison
Journal:  Nat Protoc       Date:  2017-10-26       Impact factor: 13.491

5.  Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid.

Authors:  Alex Aw; Marshall Fritz; Jonathan W Napoline; Pamela Pollet; Charles L Liotta
Journal:  J Vis Exp       Date:  2017-11-15       Impact factor: 1.355

Review 6.  An update on coating/manufacturing techniques of microneedles.

Authors:  Tamara N Tarbox; Alan B Watts; Zhengrong Cui; Robert O Williams
Journal:  Drug Deliv Transl Res       Date:  2018-12       Impact factor: 4.617

7.  Continuous Manufacturing of Ketoprofen Delayed Release Pellets Using Melt Extrusion Technology: Application of QbD Design Space, Inline Near Infrared, and Inline Pellet Size Analysis.

Authors:  Anh Q Vo; Gerd Kutz; Herman He; Sagar Narala; Suresh Bandari; Michael A Repka
Journal:  J Pharm Sci       Date:  2020-09-08       Impact factor: 3.534

8.  Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle.

Authors:  Sergey V Tsukanov; Martin D Johnson; Scott A May; Morgan Rosemeyer; Michael A Watkins; Stanley P Kolis; Matthew H Yates; Jeffrey N Johnston
Journal:  Org Process Res Dev       Date:  2016-02-01       Impact factor: 3.317

9.  Revealing Polymorphic Phase Transformations in Polymer-Based Hot Melt Extrusion Processes.

Authors:  José R Hernández Espinell; Vilmalí López-Mejías; Torsten Stelzer
Journal:  Cryst Growth Des       Date:  2018-03-09       Impact factor: 4.076

Review 10.  Advances in Twin-Screw Granulation Processing.

Authors:  Uttom Nandi; Vivek Trivedi; Steven A Ross; Dennis Douroumis
Journal:  Pharmaceutics       Date:  2021-04-27       Impact factor: 6.321
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