Literature DB >> 24115324

Selective imaging of the angiogenic relevant integrins α5β1 and αvβ3.

Stefanie Neubauer1, Florian Rechenmacher, Ambros J Beer, Flavio Curnis, Karolin Pohle, Calogero D'Alessandria, Hans-Jürgen Wester, Ute Reuning, Angelo Corti, Markus Schwaiger, Horst Kessler.   

Abstract

Pattern seekers: For the two angiogenic relevant integrins α5β1 and αvβ3, functionalized derivatives of the selective antagonists 1 and 2 could target and discriminate between tumor cells in vivo based on their different integrin patterns and also delay tumor growth in vivo. In addition, the first α5β1-selective integrin antagonist that enables specific molecular imaging by positron emission tomography was developed.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  RGD sequence; angiogenesis; integrins; peptidomimetics; positron emission tomography

Mesh：

Substances：

Year:  2013        PMID： 24115324     DOI： 10.1002/anie.201306376

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  12 in total

Review 1.  PET and SPECT imaging of melanoma: the state of the art.

Authors:  Weijun Wei; Emily B Ehlerding; Xiaoli Lan; Quanyong Luo; Weibo Cai
Journal:  Eur J Nucl Med Mol Imaging       Date:  2017-10-30       Impact factor: 9.236

2.  Integrin α5β1 and p53 convergent pathways in the control of anti-apoptotic proteins PEA-15 and survivin in high-grade glioma.

Authors:  G Renner; H Janouskova; F Noulet; V Koenig; E Guerin; S Bär; J Nuesch; F Rechenmacher; S Neubauer; H Kessler; A-F Blandin; L Choulier; N Etienne-Selloum; M Lehmann; I Lelong-Rebel; S Martin; M Dontenwill
Journal:  Cell Death Differ       Date:  2015-10-16       Impact factor: 15.828

3.  In vivo biokinetic and metabolic characterization of the ⁶⁸Ga-labelled α5β1-selective peptidomimetic FR366.

Authors:  Calogero D'Alessandria; Karolin Pohle; Florian Rechenmacher; Stefanie Neubauer; Johannes Notni; Hans-Jürgen Wester; Markus Schwaiger; Horst Kessler; Ambros J Beer
Journal:  Eur J Nucl Med Mol Imaging       Date:  2015-10-24       Impact factor: 9.236

4.  H-CRRETAWAC-OH, a lead structure for the development of radiotracer targeting integrin α5β1?

Authors:  Roland Haubner; Simone Maschauer; Jürgen Einsiedel; Iris E Eder; Christine Rangger; Peter Gmeiner; Irene J Virgolini; Olaf Prante
Journal:  Biomed Res Int       Date:  2014-10-13       Impact factor: 3.411

5.  Interface Immobilization Chemistry of cRGD-based Peptides Regulates Integrin Mediated Cell Adhesion.

Authors:  Diego Pallarola; Alexander Bochen; Heike Boehm; Florian Rechenmacher; Tariq R Sobahi; Joachim P Spatz; Horst Kessler
Journal:  Adv Funct Mater       Date:  2013-10-16       Impact factor: 18.808

6.  Non-invasive assessment of inter-and intrapatient variability of integrin expression in metastasized prostate cancer by PET.

Authors:  Ambros J Beer; Sarah M Schwarzenböck; Niko Zantl; Michael Souvatzoglou; Tobias Maurer; Petra Watzlowik; Horst Kessler; Hans-Jürgen Wester; Markus Schwaiger; Bernd Joachim Krause
Journal:  Oncotarget       Date:  2016-05-10

7.  A Comprehensive Evaluation of the Activity and Selectivity Profile of Ligands for RGD-binding Integrins.

Authors:  Tobias G Kapp; Florian Rechenmacher; Stefanie Neubauer; Oleg V Maltsev; Elisabetta A Cavalcanti-Adam; Revital Zarka; Ute Reuning; Johannes Notni; Hans-Jürgen Wester; Carlos Mas-Moruno; Joachim Spatz; Benjamin Geiger; Horst Kessler
Journal:  Sci Rep       Date:  2017-01-11       Impact factor: 4.379

Review 8.  PET radiopharmaceuticals for imaging integrin expression: tracers in clinical studies and recent developments.

Authors:  Roland Haubner; Simone Maschauer; Olaf Prante
Journal:  Biomed Res Int       Date:  2014-06-11       Impact factor: 3.411

Review 9.  Exploring the Role of RGD-Recognizing Integrins in Cancer.

Authors:  Markus Nieberler; Ute Reuning; Florian Reichart; Johannes Notni; Hans-Jürgen Wester; Markus Schwaiger; Michael Weinmüller; Andreas Räder; Katja Steiger; Horst Kessler
Journal:  Cancers (Basel)       Date:  2017-09-04       Impact factor: 6.639

10.  Selective binding and lateral clustering of α5β1 and αvβ3 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly.

Authors:  Viktoria Schaufler; Helmi Czichos-Medda; Vera Hirschfeld-Warnecken; Stefanie Neubauer; Florian Rechenmacher; Rebecca Medda; Horst Kessler; Benjamin Geiger; Joachim P Spatz; E Ada Cavalcanti-Adam
Journal:  Cell Adh Migr       Date:  2016-03-22       Impact factor: 3.405
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