BACKGROUND: Treatment options for early glottic cancer include transoral microsurgery or radiotherapy (RT). There is continuing debate about which is the superior treatment. METHODS: The literature was searched from 1996 to 2011 using MEDLINE, EMBASE, and Cochrane Library. A quality assessment of each included study was conducted and reported. RESULTS: There is no evidence in favor of 1 treatment modality when considering likelihood of local control or overall survival. There is a suggestion that RT may be associated with less measureable perturbation of voice as compared to surgery, but no significant differences were seen in patient perception. The likelihood of laryngeal preservation may be higher when surgery can be offered as initial treatment. CONCLUSION: For patients with early (T1) glottic cancer, treatment options include the equally effective endolaryngeal surgery, with or without laser, or radiation therapy. The choice between treatment modalities should be based on patient and clinician preferences and general medical condition.
BACKGROUND: Treatment options for early glottic cancer include transoral microsurgery or radiotherapy (RT). There is continuing debate about which is the superior treatment. METHODS: The literature was searched from 1996 to 2011 using MEDLINE, EMBASE, and Cochrane Library. A quality assessment of each included study was conducted and reported. RESULTS: There is no evidence in favor of 1 treatment modality when considering likelihood of local control or overall survival. There is a suggestion that RT may be associated with less measureable perturbation of voice as compared to surgery, but no significant differences were seen in patient perception. The likelihood of laryngeal preservation may be higher when surgery can be offered as initial treatment. CONCLUSION: For patients with early (T1) glottic cancer, treatment options include the equally effective endolaryngeal surgery, with or without laser, or radiation therapy. The choice between treatment modalities should be based on patient and clinician preferences and general medical condition.
Authors: Matthew T Greulich; Noah P Parker; Philip Lee; Albert L Merati; Stephanie Misono Journal: Otolaryngol Head Neck Surg Date: 2015-04-02 Impact factor: 3.497
Authors: Mohamed Shelan; Lukas Anschuetz; Adrian D Schubert; Beat Bojaxhiu; Alan Dal Pra; Frank Behrensmeier; Daniel M Aebersold; Roland Giger; Olgun Elicin Journal: Strahlenther Onkol Date: 2017-05-04 Impact factor: 3.621
Authors: Carlos Suárez; Robert P Takes; Carl E Silver; Juan P Rodrigo; Primož Strojan; Julia A Woolgar; Missak Haigentz; H Hakan Coskun; Remco de Bree; Randall P Owen; Mohamed N Elsheikh; Ashok R Shaha; Alessandra Rinaldo; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2014-02-04 Impact factor: 2.503
Authors: William M Mendenhall; Robert P Takes; Jatin P Shah; Patrick J Bradley; Jonathan J Beitler; Primož Strojan; Carlos Suárez; Juan P Rodrigo; Nabil F Saba; Alessandra Rinaldo; Jochen A Werner; Alfio Ferlito Journal: Eur Arch Otorhinolaryngol Date: 2014-11-08 Impact factor: 2.503
Authors: Laura Warner; Jessal Chudasama; Charles G Kelly; Sean Loughran; Kenneth McKenzie; Richard Wight; Paola Dey Journal: Cochrane Database Syst Rev Date: 2014-12-12