Literature DB >> 24114927

1H and 13C NMR investigation of 20-hydroxyecdysone dioxolane derivatives, a novel group of MDR modulator agents.

Attila Balázs1, Attila Hunyadi, József Csábi, Nikoletta Jedlinszki, Ana Martins, András Simon, Gábor Tóth.   

Abstract

The synthesis, structure elucidation and the complete (1)H and (13)C signal assignment of a series of dioxolane derivatives of 20-hydroxyecdysone, synthesized as novel modulators of multidrug resistance, are presented. The structures and NMR signal assignment were established by comprehensive one-dimensional and two-dimensional NMR spectroscopy supported by mass spectrometry.
Copyright © 2013 John Wiley & Sons, Ltd.

Entities:  

Keywords:  13C NMR; 1H NMR; 20-hydroxyecdysone dioxolanes; P-glycoprotein; antitumor agents; stereochemistry

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Year:  2013        PMID： 24114927     DOI： 10.1002/mrc.4015

Source DB:  PubMed          Journal:  Magn Reson Chem        ISSN： 0749-1581            Impact factor:   2.447


  4 in total

1.  Ecdysteroids sensitize MDR and non-MDR cancer cell lines to doxorubicin, paclitaxel, and vincristine but tend to protect them from cisplatin.

Authors:  Ana Martins; Péter Sipos; Katalin Dér; József Csábi; Walter Miklos; Walter Berger; Attila Zalatnai; Leonard Amaral; Joseph Molnár; Piroska Szabó-Révész; Attila Hunyadi
Journal:  Biomed Res Int       Date:  2015-05-17       Impact factor: 3.411

2.  Backstabbing P-gp: Side-Chain Cleaved Ecdysteroid 2,3-Dioxolanes Hyper-Sensitize MDR Cancer Cells to Doxorubicin without Efflux Inhibition.

Authors:  Attila Hunyadi; József Csábi; Ana Martins; Joseph Molnár; Attila Balázs; Gábor Tóth
Journal:  Molecules       Date:  2017-01-25       Impact factor: 4.411

3.  Synthesis and structure-activity relationships of novel ecdysteroid dioxolanes as MDR modulators in cancer.

Authors:  Ana Martins; József Csábi; Attila Balázs; Diána Kitka; Leonard Amaral; József Molnár; András Simon; Gábor Tóth; Attila Hunyadi
Journal:  Molecules       Date:  2013-12-10       Impact factor: 4.411

Review 4.  Phytoecdysteroids: Distribution, Structural Diversity, Biosynthesis, Activity, and Crosstalk with Phytohormones.

Authors:  Yamshi Arif; Priyanka Singh; Andrzej Bajguz; Shamsul Hayat
Journal:  Int J Mol Sci       Date:  2022-08-04       Impact factor: 6.208
  4 in total

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