Literature DB >> 24112984

Rapamycin resistance: mTORC1 substrates hold some of the answers.

Sang-Oh Yoon1, Philippe P Roux.   

Abstract

The mechanism of action of the mTOR inhibitor rapamycin is poorly understood and why certain mTORC1 phosphorylation sites are rapamycin insensitive remains elusive. Site-specific analysis of mTORC1 substrates now suggests that the sequence composition of a phosphorylation site determines whether it is sensitive to rapamycin and starvation.
Copyright © 2013 Elsevier Ltd. All rights reserved.

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Year:  2013        PMID： 24112984     DOI： 10.1016/j.cub.2013.08.030

Source DB:  PubMed          Journal:  Curr Biol        ISSN： 0960-9822            Impact factor:   10.834


  15 in total

1.  Continuous administration of the mTORC1 inhibitor everolimus induces tolerance and decreases autophagy in mice.

Authors:  Ammar Kurdi; Mireille De Doncker; Arthur Leloup; Hugo Neels; Jean-Pierre Timmermans; Katrien Lemmens; Sandra Apers; Guido R Y De Meyer; Wim Martinet
Journal:  Br J Pharmacol       Date:  2016-10-23       Impact factor: 8.739

Review 2.  4E-BP1, a multifactor regulated multifunctional protein.

Authors:  Xiaoyu Qin; Bin Jiang; Yanjie Zhang
Journal:  Cell Cycle       Date:  2016       Impact factor: 4.534

3.  The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes.

Authors:  Lomon So; Jongdae Lee; Miguel Palafox; Sharmila Mallya; Chaz G Woxland; Meztli Arguello; Morgan L Truitt; Nahum Sonenberg; Davide Ruggero; David A Fruman
Journal:  Sci Signal       Date:  2016-05-31       Impact factor: 8.192

4.  Blocking rpS6 Phosphorylation Exacerbates Tsc1 Deletion-Induced Kidney Growth.

Authors:  Huijuan Wu; Jianchun Chen; Jinxian Xu; Zheng Dong; Oded Meyuhas; Jian-Kang Chen
Journal:  J Am Soc Nephrol       Date:  2015-08-21       Impact factor: 10.121

Review 5.  Targeting the translation machinery in cancer.

Authors:  Mamatha Bhat; Nathaniel Robichaud; Laura Hulea; Nahum Sonenberg; Jerry Pelletier; Ivan Topisirovic
Journal:  Nat Rev Drug Discov       Date:  2015-03-06       Impact factor: 84.694

Review 6.  Regulation of global and specific mRNA translation by the mTOR signaling pathway.

Authors:  Neethi Nandagopal; Philippe P Roux
Journal:  Translation (Austin)       Date:  2015-02-02

Review 7.  Growing knowledge of the mTOR signaling network.

Authors:  Kezhen Huang; Diane C Fingar
Journal:  Semin Cell Dev Biol       Date:  2014-09-19       Impact factor: 7.727

8.  Effect of mTOR inhibitors in nude mice with endometrial carcinoma and variable PTEN expression status.

Authors:  Pedro Fong; Li-rong Meng
Journal:  Med Sci Monit Basic Res       Date:  2014-09-30

9.  GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.

Authors:  Clare Stretton; Thorsten M Hoffmann; Michael J Munson; Alan Prescott; Peter M Taylor; Ian G Ganley; Harinder S Hundal
Journal:  Biochem J       Date:  2015-07-09       Impact factor: 3.857

Review 10.  Signaling Pathways Involved in the Regulation of mRNA Translation.

Authors:  Philippe P Roux; Ivan Topisirovic
Journal:  Mol Cell Biol       Date:  2018-05-29       Impact factor: 4.272
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